InnateDB Protein
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IDBP-366103.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TAF4B
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Protein Name
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TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
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Synonyms
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SPGF13; TAF2C2; TAFII105;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000389365
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InnateDB Gene
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IDBG-1811 (TAF4B)
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Protein Structure
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Function |
Cell type-specific subunit of TFIID that may function as a gene-selective coactivator in certain cells. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TAFII105 is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating folliculogenesis. Through interaction with OCBA/POU2AF1, acts as a coactivator of B-cell-specific transcription. {ECO:0000269PubMed:10828057, ECO:0000269PubMed:10849440, ECO:0000269PubMed:16088961}.
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Subcellular Localization |
Nucleus. Cytoplasm. Note=Export into the cytoplasm is mediated by a CRM1-independent nuclear export pathway and not by phosphorylation.
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Disease Associations |
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Tissue Specificity |
Preferentially expressed in ovarian granulosa cells (at protein level). Highly expressed in B-cells. {ECO:0000269PubMed:16088961, ECO:0000269PubMed:8858156}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
8
[view]
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Protein-Protein |
7
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR003894
TAFH/NHR1
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PFAM |
PF07531
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PRINTS |
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PIRSF |
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SMART |
SM00549
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TIGRFAMs |
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Modification |
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SwissProt |
Q92750
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PhosphoSite |
PhosphoSite-Q92750
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TrEMBL |
A4PBF8
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UniProt Splice Variant |
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Entrez Gene |
6875
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UniGene |
Hs.604391
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RefSeq |
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HUGO |
HGNC:11538
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OMIM |
601689
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AB234097
AY888048
AY888049
Y09321
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GenPept |
AAX14897
AAX14898
BAF51562
CAA70499
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