InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TAF4B

Summary

InnateDB Gene

IDBG-1811.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TAF4B

Gene Name

TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa

Synonyms

SPGF13; TAF2C2; TAFII105

Species

Homo sapiens

Ensembl Gene

ENSG00000141384

Encoded Proteins

IDBP-1813

TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa

IDBP-228192

TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa

IDBP-366103

TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa

IDBP-726622

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

TATA binding protein (TBP) and TBP-associated factors (TAFs) participate in the formation of the TFIID protein complex, which is involved in initiation of transcription of genes by RNA polymerase II. This gene encodes a cell type-specific TAF that may be responsible for mediating transcription by a subset of activators in B cells. [provided by RefSeq, Sep 2011]
TATA binding protein (TBP) and TBP-associated factors (TAFs) participate in the formation of the TFIID protein complex, which is involved in initiation of transcription of genes by RNA polymerase II. This gene encodes a cell type-specific TAF that may be responsible for mediating transcription by a subset of activators in B cells. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:26225936-26391685

Strand

Forward strand

Band

q11.2

Transcripts

ENST00000269142	ENSP00000269142
ENST00000400466	ENSP00000383314
ENST00000418698	ENSP00000389365
ENST00000578121	ENSP00000462980

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	7 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0046982	protein heterodimerization activity
GO:0051059	NF-kappaB binding

Biological Process

GO:0006352	DNA-templated transcription, initiation
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006368	transcription elongation from RNA polymerase II promoter
GO:0010467	gene expression
GO:0016032	viral process