Homo sapiens Gene: TAF4B
Summary
InnateDB Gene IDBG-1811.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TAF4B
Gene Name TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
Synonyms SPGF13; TAF2C2; TAFII105;
Species Homo sapiens
Ensembl Gene ENSG00000141384
Encoded Proteins
TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary TATA binding protein (TBP) and TBP-associated factors (TAFs) participate in the formation of the TFIID protein complex, which is involved in initiation of transcription of genes by RNA polymerase II. This gene encodes a cell type-specific TAF that may be responsible for mediating transcription by a subset of activators in B cells. [provided by RefSeq, Sep 2011]
TATA binding protein (TBP) and TBP-associated factors (TAFs) participate in the formation of the TFIID protein complex, which is involved in initiation of transcription of genes by RNA polymerase II. This gene encodes a cell type-specific TAF that may be responsible for mediating transcription by a subset of activators in B cells. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:26225936-26391685
Strand Forward strand
Band q11.2
Transcripts
ENST00000269142 ENSP00000269142
ENST00000400466 ENSP00000383314
ENST00000418698 ENSP00000389365
ENST00000578121 ENSP00000462980
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0046982 protein heterodimerization activity
GO:0051059 NF-kappaB binding
Biological Process
GO:0006352 DNA-templated transcription, initiation
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006368 transcription elongation from RNA polymerase II promoter
GO:0010467 gene expression
GO:0016032 viral process
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005669 transcription factor TFIID complex
GO:0005730 nucleolus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
RNA Polymerase II Transcription Initiation pathway
Late Phase of HIV Life Cycle pathway
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening pathway
RNA Polymerase II Transcription pathway
RNA Polymerase II HIV Promoter Escape pathway
RNA Polymerase II Promoter Escape pathway
HIV Life Cycle pathway
RNA Polymerase II Pre-transcription Events pathway
Transcription of the HIV genome pathway
HIV Infection pathway
HIV Transcription Initiation pathway
Gene Expression pathway
Disease pathway
RNA Polymerase II Transcription Initiation And Promoter Clearance pathway
KEGG
Basal transcription factors pathway
Huntington's disease pathway
INOH
PID BIOCARTA
PID NCI
Validated targets of C-MYC transcriptional activation
Cross-References
SwissProt Q92750
TrEMBL A4PBF8
UniProt Splice Variant
Entrez Gene 6875
UniGene Hs.369519 Hs.604391
RefSeq NM_001293725 NM_005640 XM_005258339 XM_006722528
HUGO HGNC:11538
OMIM 601689
CCDS CCDS42421
HPRD
IMGT
EMBL AB234097 AY888048 AY888049 Y09321
GenPept AAX14897 AAX14898 BAF51562 CAA70499
RNA Seq Atlas 6875