InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HDAC9

Summary

InnateDB Protein

IDBP-366819.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HDAC9

Protein Name

histone deacetylase 9

Synonyms

HD7; HD7b; HD9; HDAC; HDAC7; HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR;

Species

Homo sapiens

Ensembl Protein

ENSP00000410337

InnateDB Gene

IDBG-9049 (HDAC9)

Protein Structure

UniProt Annotation

Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription.Isoform 3 lacks active site residues and therefore is catalytically inactive. Represses MEF2-dependent transcription by recruiting HDAC1 and/or HDAC3. Seems to inhibit skeletal myogenesis and to be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Note=A chromosomal aberration involving HDAC9 is found in a family with Peters anomaly. Translocation t(1;7)(q41;p21) with TGFB2 resulting in lack of HDAC9 protein.

Tissue Specificity

Broadly expressed, with highest levels in brain, heart, muscle and testis. Isoform 3 is present in human bladder carcinoma cells (at protein level). {ECO:0000269PubMed:10655483, ECO:0000269PubMed:11535832, ECO:0000269PubMed:12590135, ECO:0000269PubMed:12706107}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 117 experimentally validated interaction(s) in this database.

Experimentally validated
Total	117 [view]
Protein-Protein	78 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	38 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003714	transcription corepressor activity
GO:0004407	histone deacetylase activity
GO:0005080	protein kinase C binding
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0033558	protein deacetylase activity
GO:0042826	histone deacetylase binding
GO:0046872	metal ion binding
GO:0046969	NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0046970	NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0070491	repressing transcription factor binding
GO:0097372	NAD-dependent histone deacetylase activity (H3-K18 specific)

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006954	inflammatory response
GO:0007219	Notch signaling pathway
GO:0007507	heart development
GO:0016568	chromatin modification
GO:0016575	histone deacetylation
GO:0030183	B cell differentiation
GO:0032869	cellular response to insulin stimulus
GO:0034983	peptidyl-lysine deacetylation
GO:0042113	B cell activation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0048742	regulation of skeletal muscle fiber development
GO:0051153	regulation of striated muscle cell differentiation
GO:0070932	histone H3 deacetylation
GO:0070933	histone H4 deacetylation
GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis

Cellular Component

GO:0000118	histone deacetylase complex
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005667	transcription factor complex
GO:0005737	cytoplasm
GO:0035097	histone methyltransferase complex

Protein Structure and Domains

PDB ID

InterPro

IPR000286 Histone deacetylase superfamily
IPR017320 Histone deacetylase class II, eukaryotic
IPR023801 Histone deacetylase domain
IPR024643 Histone deacetylase, glutamine rich N-terminal domain

PFAM

PF00850
PF12203

PRINTS

PR01270

PIRSF

PIRSF037911

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt