InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NKIRAS1

Summary

InnateDB Protein

IDBP-367711.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NKIRAS1

Protein Name

NFKB inhibitor interacting Ras-like 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000400385

InnateDB Gene

IDBG-22073 (NKIRAS1)

Protein Structure

UniProt Annotation

Function

Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB. {ECO:0000269PubMed:10657303, ECO:0000269PubMed:12672800, ECO:0000269PubMed:15024091}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:15024091}.

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:10657303}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	11 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005525	GTP binding

Biological Process

GO:0006184	GTP catabolic process
GO:0007165	signal transduction
GO:0007249	I-kappaB kinase/NF-kappaB signaling
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005575	cellular_component
GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001806 Small GTPase superfamily
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR013684 Mitochondrial Rho-like
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00071
PF00025
PF08477

PRINTS

PR00449
PR00328

PIRSF

SMART

SM00175
SM00173

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt