InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PIK3R5

Summary

InnateDB Protein

IDBP-368109.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PIK3R5

Protein Name

phosphoinositide-3-kinase, regulatory subunit 5

Synonyms

F730038I15Rik; FOAP-2; p101; P101-PI3K;

Species

Homo sapiens

Ensembl Protein

ENSP00000392812

InnateDB Gene

IDBG-29574 (PIK3R5)

Protein Structure

UniProt Annotation

Function

Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.

Disease Associations

Ataxia-oculomotor apraxia 3 (AOA3) [MIM:615217]: An autosomal recessive disease characterized by cerebellar ataxia, oculomotor apraxia, areflexia and peripheral neuropathy. {ECO:0000269PubMed:22065524}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Ubiquitously expressed with high expression in fetal brain compared to adult brain. Abundant expression is observed in cerebellum, cerebral cortex, cerebral meninges, and vermis cerebelli. {ECO:0000269PubMed:15797027, ECO:0000269PubMed:22065524}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0031683	G-protein beta/gamma-subunit complex binding
GO:0046935	1-phosphatidylinositol-3-kinase regulator activity

Biological Process

GO:0006644	phospholipid metabolic process
GO:0006661	phosphatidylinositol biosynthetic process
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007596	blood coagulation
GO:0008219	cell death
GO:0014065	phosphatidylinositol 3-kinase signaling
GO:0030168	platelet activation
GO:0043406	positive regulation of MAP kinase activity
GO:0043551	regulation of phosphatidylinositol 3-kinase activity
GO:0044281	small molecule metabolic process
GO:0051897	positive regulation of protein kinase B signaling

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005942	phosphatidylinositol 3-kinase complex
GO:0005944	1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex
GO:0016020	membrane