Homo sapiens Gene: PIK3R5
Summary
InnateDB Gene IDBG-29574.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PIK3R5
Gene Name phosphoinositide-3-kinase, regulatory subunit 5
Synonyms F730038I15Rik; FOAP-2; p101; P101-PI3K;
Species Homo sapiens
Ensembl Gene ENSG00000141506
Encoded Proteins
phosphoinositide-3-kinase, regulatory subunit 5
phosphoinositide-3-kinase, regulatory subunit 5
phosphoinositide-3-kinase, regulatory subunit 5
phosphoinositide-3-kinase, regulatory subunit 5
phosphoinositide-3-kinase, regulatory subunit 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Phosphatidylinositol 3-kinases (PI3Ks) phosphorylate the inositol ring of phosphatidylinositol at the 3-prime position, and play important roles in cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. The PI3Ks are divided into three classes: I, II and III, and only the class I PI3Ks are involved in oncogenesis. This gene encodes the 101 kD regulatory subunit of the class I PI3K gamma complex, which is a dimeric enzyme, consisting of a 110 kD catalytic subunit gamma and a regulatory subunit of either 55, 87 or 101 kD. This protein recruits the catalytic subunit from the cytosol to the plasma membrane through high-affinity interaction with G-beta-gamma proteins. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:8878911-8965712
Strand Reverse strand
Band p13.1
Transcripts
ENST00000269300 ENSP00000269300
ENST00000447110 ENSP00000392812
ENST00000584803 ENSP00000462680
ENST00000583039
ENST00000583222
ENST00000581895 ENSP00000461966
ENST00000583812
ENST00000581552 ENSP00000462433
ENST00000578457
ENST00000580959
ENST00000583810
ENST00000577981
ENST00000577214
ENST00000585260 ENSP00000462824
ENST00000578515
ENST00000578743
ENST00000584456
ENST00000623421 ENSP00000485280
ENST00000616147 ENSP00000484211
ENST00000611902 ENSP00000477795
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0031683 G-protein beta/gamma-subunit complex binding
GO:0046935 1-phosphatidylinositol-3-kinase regulator activity
Biological Process
GO:0006644 phospholipid metabolic process
GO:0006661 phosphatidylinositol biosynthetic process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007596 blood coagulation
GO:0008219 cell death
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0030168 platelet activation
GO:0043406 positive regulation of MAP kinase activity
GO:0043551 regulation of phosphatidylinositol 3-kinase activity
GO:0044281 small molecule metabolic process
GO:0051897 positive regulation of protein kinase B signaling
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005942 phosphatidylinositol 3-kinase complex
GO:0005944 1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Metabolism of lipids and lipoproteins pathway
Synthesis of PIPs at the plasma membrane pathway
Signaling by GPCR pathway
Platelet activation, signaling and aggregation pathway
G-protein beta:gamma signalling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
GPVI-mediated activation cascade pathway
PI Metabolism pathway
Phospholipid metabolism pathway
Metabolism pathway
G beta:gamma signalling through PI3Kgamma pathway
Hemostasis pathway
KEGG
ErbB signaling pathway pathway
Chemokine signaling pathway pathway
Phosphatidylinositol signaling system pathway
mTOR signaling pathway pathway
Apoptosis pathway
VEGF signaling pathway pathway
Osteoclast differentiation pathway
Focal adhesion pathway
Toll-like receptor signaling pathway pathway
Jak-STAT signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
T cell receptor signaling pathway pathway
B cell receptor signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Fc gamma R-mediated phagocytosis pathway
Leukocyte transendothelial migration pathway
Neurotrophin signaling pathway pathway
Regulation of actin cytoskeleton pathway
Insulin signaling pathway pathway
Progesterone-mediated oocyte maturation pathway
Type II diabetes mellitus pathway
Aldosterone-regulated sodium reabsorption pathway
Carbohydrate digestion and absorption pathway
Bacterial invasion of epithelial cells pathway
Chagas disease (American trypanosomiasis) pathway
Toxoplasmosis pathway
Amoebiasis pathway
Hepatitis C pathway
Pathways in cancer pathway
Colorectal cancer pathway
Renal cell carcinoma pathway
Pancreatic cancer pathway
Endometrial cancer pathway
Glioma pathway
Prostate cancer pathway
Melanoma pathway
Chronic myeloid leukemia pathway
Acute myeloid leukemia pathway
Small cell lung cancer pathway
Non-small cell lung cancer pathway
INOH
Inositol phosphate metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.738684
RefSeq NM_001142633 NM_001251851 NM_001251852 NM_001251853 NM_001251855 NM_014308 XM_005256579 XM_005256580
HUGO
OMIM
CCDS CCDS11147 CCDS73986
HPRD 11433
IMGT
EMBL
GenPept
RNA Seq Atlas