Version 5.4
Homo sapiens Protein: GAS7
Summary
InnateDB Protein IDBP-368360.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GAS7
Protein Name growth arrest-specific 7
Synonyms MLL/GAS7;
Species Homo sapiens
Ensembl Protein ENSP00000407552
InnateDB Gene IDBG-29999 (GAS7)
Protein Structure
UniProt Annotation
Function May play a role in promoting maturation and morphological differentiation of cerebellar neurons.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations Note=A chromosomal aberration involving GAS7 is found in acute myeloid leukemia. Translocation t(11;17)(q23;p13) with KMT2A/MLL1.
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
Experimentally validated
Total 38 [view]
Protein-Protein 38 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0051015 actin filament binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0007050 cell cycle arrest
GO:0008360 regulation of cell shape
GO:0030041 actin filament polymerization
GO:0030182 neuron differentiation
GO:0048812 neuron projection morphogenesis
GO:0051017 actin filament bundle assembly
Cellular Component
GO:0001726 ruffle
GO:0005737 cytoplasm
GO:0005884 actin filament
Protein Structure and Domains
PDB ID
InterPro IPR001060 FCH domain
IPR001202 WW domain
IPR001452 SH3 domain
IPR011511 Variant SH3 domain
PFAM PF00611
PF00397
PF00018
PF14604
PF07653
PRINTS PR00452
PIRSF
SMART SM00055
SM00456
SM00326
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O60861
PhosphoSite PhosphoSite-O60861
TrEMBL J3QS26
UniProt Splice Variant
Entrez Gene 8522
UniGene Hs.618996
RefSeq NP_958839
HUGO HGNC:4169
OMIM 603127
CCDS CCDS11152
HPRD 16011
IMGT
EMBL AB007854 AC000003 AC005747 AC026591 AC083783 AC107938 AF231998 AJ224876 AK292987 AK293755 AK315162 AY327406 BC001152 BC006454 BT006891 CH471108
GenPept AAG26332 AAH01152 AAH06454 AAP35537 AAP92798 BAA23690 BAF85676 BAG37606 BAH11588 CAA12177 EAW90011 EAW90012 EAW90013

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca