Version 5.4
Homo sapiens Protein: SLC14A1
Summary
InnateDB Protein IDBP-368389.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC14A1
Protein Name solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
Synonyms HsT1341; HUT11; JK; RACH1; RACH2; UT-B1; UT1; UTE;
Species Homo sapiens
Ensembl Protein ENSP00000412309
InnateDB Gene IDBG-2812 (SLC14A1)
Protein Structure
UniProt Annotation
Function Urea channel that facilitates transmembrane urea transport down a concentration gradient. A constriction of the transmembrane channel functions as selectivity filter through which urea is expected to pass in dehydrated form. The rate of urea conduction is increased by hypotonic stress. Plays an important role in the kidney medulla collecting ducts, where it allows rapid equilibration between the lumen of the collecting ducts and the interstitium, and thereby prevents water loss driven by the high concentration of urea in the urine. Facilitates urea transport across erythrocyte membranes. May also play a role in transmembrane water transport, possibly by indirect means.
Subcellular Localization Cell membrane {ECO:0000269PubMed:23219802}; Multi-pass membrane protein {ECO:0000269PubMed:23219802}. Basolateral cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Restricted to the basolateral membrane in various portions of the urothelium. {ECO:0000250}.
Disease Associations
Tissue Specificity Detected in erythrocytes (at protein level). Erythrocytes. {ECO:0000269PubMed:23219802}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0015204 urea transmembrane transporter activity
GO:0015265 urea channel activity
Biological Process
GO:0015840 urea transport
GO:0055085 transmembrane transport
GO:0071918 urea transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR004937 Urea transporter
PFAM PF03253
PRINTS
PIRSF PIRSF016502
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q13336
PhosphoSite PhosphoSite-Q13336
TrEMBL Q96KQ5
UniProt Splice Variant
Entrez Gene 6563
UniGene Hs.600667
RefSeq NP_001122060
HUGO HGNC:10918
OMIM 613868
CCDS CCDS45860
HPRD 00195
IMGT
EMBL AC023421 AF046026 AF328890 AJ316564 AK091064 AK123681 AK289608 AK294129 AY942197 BC050539 CH471088 EF571316 EF571317 EF571318 GQ502682 HE577851 JN104323 JN571298 L36121 U35735 Y19039
GenPept AAB00181 AAC69610 AAH50539 AAL37474 AAX20112 ACV91713 AEN14346 AFN89222 BAF82297 BAG52274 BAG53935 BAG57459 CAB60834 CAC86943 CCD04138 EAX01458

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca