InnateDB Protein
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IDBP-368391.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SLC14A1
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Protein Name
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solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
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Synonyms
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HsT1341; HUT11; JK; RACH1; RACH2; UT-B1; UT1; UTE;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000390637
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InnateDB Gene
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IDBG-2812 (SLC14A1)
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Protein Structure
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Function |
Urea channel that facilitates transmembrane urea transport down a concentration gradient. A constriction of the transmembrane channel functions as selectivity filter through which urea is expected to pass in dehydrated form. The rate of urea conduction is increased by hypotonic stress. Plays an important role in the kidney medulla collecting ducts, where it allows rapid equilibration between the lumen of the collecting ducts and the interstitium, and thereby prevents water loss driven by the high concentration of urea in the urine. Facilitates urea transport across erythrocyte membranes. May also play a role in transmembrane water transport, possibly by indirect means.
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Subcellular Localization |
Cell membrane {ECO:0000269PubMed:23219802}; Multi-pass membrane protein {ECO:0000269PubMed:23219802}. Basolateral cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Restricted to the basolateral membrane in various portions of the urothelium. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Detected in erythrocytes (at protein level). Erythrocytes. {ECO:0000269PubMed:23219802}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
Accession |
GO Term |
GO:0005372
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water transmembrane transporter activity
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GO:0015204
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urea transmembrane transporter activity
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GO:0015265
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urea channel activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR004937
Urea transporter
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PFAM |
PF03253
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PRINTS |
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PIRSF |
PIRSF016502
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q13336
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PhosphoSite |
PhosphoSite-Q13336
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TrEMBL |
Q96KQ5
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UniProt Splice Variant |
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Entrez Gene |
6563
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UniGene |
Hs.600667
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RefSeq |
NP_001139509
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HUGO |
HGNC:10918
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OMIM |
613868
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CCDS |
CCDS45860
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HPRD |
00195
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IMGT |
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EMBL |
AC023421
AF046026
AF328890
AJ316564
AK091064
AK123681
AK289608
AK294129
AY942197
BC050539
CH471088
EF571316
EF571317
EF571318
GQ502682
HE577851
JN104323
JN571298
L36121
U35735
Y19039
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GenPept |
AAB00181
AAC69610
AAH50539
AAL37474
AAX20112
ACV91713
AEN14346
AFN89222
BAF82297
BAG52274
BAG53935
BAG57459
CAB60834
CAC86943
CCD04138
EAX01458
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