InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ATP6V0D1

Summary

InnateDB Protein

IDBP-36844.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP6V0D1

Protein Name

ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1

Synonyms

ATP6D; ATP6DV; P39; VATX; VMA6; VPATPD;

Species

Homo sapiens

Ensembl Protein

ENSP00000290949

InnateDB Gene

IDBG-36842 (ATP6V0D1)

Protein Structure

UniProt Annotation

Function

Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis (By similarity). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000305PubMed:21844891}; Peripheral membrane protein {ECO:0000305PubMed:21844891}; Cytoplasmic side {ECO:0000305PubMed:21844891}. Note=Localizes to centrosome and the base of the cilium.

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:12384298, ECO:0000269PubMed:8250920}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	11 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism
GO:0015078	hydrogen ion transmembrane transporter activity
GO:0032403	protein complex binding

Biological Process

GO:0006879	cellular iron ion homeostasis
GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0007420	brain development
GO:0008286	insulin receptor signaling pathway
GO:0015991	ATP hydrolysis coupled proton transport
GO:0015992	proton transport
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0033572	transferrin transport
GO:0042384	cilium assembly
GO:0044267	cellular protein metabolic process
GO:0051701	interaction with host
GO:0055085	transmembrane transport
GO:0090382	phagosome maturation

Cellular Component

GO:0005765	lysosomal membrane
GO:0005769	early endosome
GO:0005813	centrosome
GO:0008021	synaptic vesicle
GO:0010008	endosome membrane
GO:0016020	membrane
GO:0016324	apical plasma membrane
GO:0016471	vacuolar proton-transporting V-type ATPase complex
GO:0030670	phagocytic vesicle membrane
GO:0033179	proton-transporting V-type ATPase, V0 domain
GO:0043005	neuron projection
GO:0043234	protein complex
GO:0043679	axon terminus
GO:0070062	extracellular vesicular exosome