InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ATP6V0D1

Summary

InnateDB Gene

IDBG-36842.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP6V0D1

Gene Name

ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1

Synonyms

ATP6D; ATP6DV; P39; VATX; VMA6; VPATPD

Species

Homo sapiens

Ensembl Gene

ENSG00000159720

Encoded Proteins

IDBP-36844

ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1

IDBP-362398

ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1

IDBP-604037

ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1

IDBP-750496

IDBP-751619

IDBP-747477

IDBP-748453

IDBP-751158

IDBP-754385

IDBP-746255

IDBP-750014

IDBP-811811

ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is known as the D subunit and is found ubiquitously. [provided by RefSeq, Jul 2008]
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c\', c\'\', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is known as the D subunit and is found ubiquitously. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:67438014-67481237

Strand

Reverse strand

Band

q22.1

Transcripts

ENST00000290949	ENSP00000290949
ENST00000426604	ENSP00000393910
ENST00000540149	ENSP00000441282
ENST00000564191	ENSP00000456695
ENST00000561658
ENST00000567694
ENST00000568101	ENSP00000457104
ENST00000567170
ENST00000564615	ENSP00000455802
ENST00000563305
ENST00000566322	ENSP00000455446
ENST00000564788	ENSP00000455695
ENST00000563064	ENSP00000457105
ENST00000561852	ENSP00000457744
ENST00000568620
ENST00000565835	ENSP00000463328
ENST00000568298
ENST00000602876	ENSP00000473515

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	11 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism
GO:0015078	hydrogen ion transmembrane transporter activity
GO:0032403	protein complex binding

Biological Process

GO:0006879	cellular iron ion homeostasis
GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0007420	brain development
GO:0008286	insulin receptor signaling pathway
GO:0015991	ATP hydrolysis coupled proton transport
GO:0015992	proton transport
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0033572	transferrin transport
GO:0042384	cilium assembly
GO:0044267	cellular protein metabolic process
GO:0051701	interaction with host
GO:0055085	transmembrane transport
GO:0090382	phagosome maturation

Cellular Component

GO:0005765	lysosomal membrane
GO:0005769	early endosome
GO:0005813	centrosome
GO:0008021	synaptic vesicle
GO:0010008	endosome membrane
GO:0016020	membrane
GO:0016324	apical plasma membrane
GO:0016471	vacuolar proton-transporting V-type ATPase complex
GO:0030670	phagocytic vesicle membrane
GO:0033179	proton-transporting V-type ATPase, V0 domain
GO:0043005	neuron projection
GO:0043234	protein complex
GO:0043679	axon terminus
GO:0070062	extracellular vesicular exosome