InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GSPT1

Summary

InnateDB Protein

IDBP-368746.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GSPT1

Protein Name

G1 to S phase transition 1

Synonyms

551G9.2; eRF3a; ETF3A; GST1;

Species

Homo sapiens

Ensembl Protein

ENSP00000398131

InnateDB Gene

IDBG-15002 (GSPT1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	37 [view]
Protein-Protein	36 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003747	translation release factor activity
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006184	GTP catabolic process
GO:0006415	translational termination
GO:0006479	protein methylation

Cellular Component

GO:0005622

intracellular

Protein Structure and Domains

PDB ID

InterPro

IPR000795 Elongation factor, GTP-binding domain
IPR004160 Translation elongation factor EFTu/EF1A, C-terminal
IPR004161 Translation elongation factor EFTu/EF1A, domain 2
IPR009000 Translation protein, beta-barrel domain
IPR009001 Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal
IPR009818 Ataxin-2, C-terminal
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00009
PF03143
PF03144
PF07145

PRINTS

PR00315

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P15170