InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IL2

Summary

InnateDB Protein

IDBP-36894.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL2

Protein Name

interleukin 2

Synonyms

IL-2; lymphokine; TCGF;

Species

Homo sapiens

Ensembl Protein

ENSP00000226730

InnateDB Gene

IDBG-36892 (IL2)

Protein Structure

UniProt Annotation

Function

Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells.

Subcellular Localization

Secreted.

Disease Associations

Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	51 [view]
Protein-Protein	17 [view]
Protein-DNA	33 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005134	interleukin-2 receptor binding
GO:0008083	growth factor activity
GO:0019209	kinase activator activity
GO:0030246	carbohydrate binding
GO:0031851	kappa-type opioid receptor binding
GO:0043208	glycosphingolipid binding

Biological Process

GO:0001933	negative regulation of protein phosphorylation
GO:0001934	positive regulation of protein phosphorylation
GO:0002903	negative regulation of B cell apoptotic process
GO:0006955	immune response
GO:0007155	cell adhesion
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007267	cell-cell signaling
GO:0008284	positive regulation of cell proliferation
GO:0030101	natural killer cell activation
GO:0030217	T cell differentiation
GO:0030307	positive regulation of cell growth
GO:0030890	positive regulation of B cell proliferation
GO:0032729	positive regulation of interferon-gamma production
GO:0032740	positive regulation of interleukin-17 production
GO:0034105	positive regulation of tissue remodeling
GO:0042102	positive regulation of T cell proliferation
GO:0042104	positive regulation of activated T cell proliferation
GO:0042523	positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0043066	negative regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0045582	positive regulation of T cell differentiation
GO:0045591	positive regulation of regulatory T cell differentiation
GO:0045822	negative regulation of heart contraction
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046013	regulation of T cell homeostatic proliferation
GO:0048304	positive regulation of isotype switching to IgG isotypes
GO:0050672	negative regulation of lymphocyte proliferation
GO:0050728	negative regulation of inflammatory response
GO:0050729	positive regulation of inflammatory response
GO:0051024	positive regulation of immunoglobulin secretion
GO:0060999	positive regulation of dendritic spine development
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand