InnateDB Protein
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IDBP-369439.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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UGT2A1
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Protein Name
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UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000387888
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InnateDB Gene
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IDBG-21898 (UGT2A1)
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Protein Structure
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Function |
UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Active on odorants and seems to be involved in olfaction; it could help clear lipophilic odorant molecules from the sensory epithelium. {ECO:0000269PubMed:19858781}.
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Subcellular Localization |
Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Olfactory epithelium and brain. Isoform 2 is mainly expressed in the nasal mucosa. {ECO:0000269PubMed:10359671, ECO:0000269PubMed:19858781}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
Accession |
GO Term |
GO:0015020
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glucuronosyltransferase activity
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GO:0016758
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transferase activity, transferring hexosyl groups
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GO:0030246
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carbohydrate binding
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002213
UDP-glucuronosyl/UDP-glucosyltransferase
IPR007235
Glycosyl transferase, family 28, C-terminal
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PFAM |
PF00201
PF04101
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Y4X1
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PhosphoSite |
PhosphoSite-Q9Y4X1
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
10941
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UniGene |
Hs.740119
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RefSeq |
NP_006789
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HUGO |
HGNC:12542
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OMIM |
604716
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CCDS |
CCDS3529
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HPRD |
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IMGT |
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EMBL |
AC093829
AJ006054
AK304249
AK314209
FJ664272
FJ664273
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GenPept |
ACV70034
ACV70035
BAG65116
CAB41974
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