Version 5.4
Homo sapiens Gene: UGT2A1
Summary
InnateDB Gene IDBG-21898.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UGT2A1
Gene Name UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000173610
Encoded Proteins
IDBP-21900
UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus
IDBP-369439
UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus
IDBP-476558
UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus
IDBP-477559
UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus
IDBP-478903
UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus
IDBP-481147
UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the UDP-glycosyltransferase family, members of which catalyze biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This enzyme is expressed in the olfactory neuroepithelium, which lines the posterior nasal cavity and is exposed to a wide range of odorants and airborne toxic compounds. Hence, this protein has been suggested to be involved in clearing lipophilic odorant molecules from the sensory epithelium. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:69588417-69653249
Strand Reverse strand
Band q13.3
Transcripts
ENST00000286604 ENSP00000286604
ENST00000457664 ENSP00000387888
ENST00000503640 ENSP00000424478
ENST00000512704 ENSP00000421432
ENST00000514019 ENSP00000425497
ENST00000502343
ENST00000514341
ENST00000505512 ENSP00000427709
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0015020 glucuronosyltransferase activity
GO:0016758 transferase activity, transferring hexosyl groups
GO:0030246 carbohydrate binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0007608 sensory perception of smell
GO:0008152 metabolic process
GO:0009593 detection of chemical stimulus
GO:0030259 lipid glycosylation
GO:0052695 cellular glucuronidation
Cellular Component
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_6784
Glucuronidation pathway
REACT_6959
Phase II conjugation pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
KEGG
hsa00830
Retinol metabolism pathway
hsa00040
Pentose and glucuronate interconversions pathway
hsa00500
Starch and sucrose metabolism pathway
hsa00140
Steroid hormone biosynthesis pathway
hsa00053
Ascorbate and aldarate metabolism pathway
hsa00980
Metabolism of xenobiotics by cytochrome P450 pathway
hsa00860
Porphyrin and chlorophyll metabolism pathway
hsa00982
Drug metabolism pathway
hsa00983
Drug metabolism pathway
INOH
PID NCI
Cross-References
SwissProt Q9Y4X1
TrEMBL
UniProt Splice Variant
Entrez Gene 10941
UniGene Hs.225950 Hs.740119
RefSeq NM_001252275 NM_001301239 NM_006798 NM_001252274
HUGO HGNC:12542
OMIM 604716
CCDS CCDS3529 CCDS58901 CCDS58902
HPRD
IMGT
EMBL AC093829 AJ006054 AK304249 AK314209 FJ664272 FJ664273
GenPept ACV70034 ACV70035 BAG65116 CAB41974
RNA Seq Atlas 10941

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca