Version 5.4
Homo sapiens Protein: B3GALT5
Summary
InnateDB Protein IDBP-3695.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol B3GALT5
Protein Name UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5
Synonyms B3GalT-V; B3GalTx; B3T5; beta-1,3-GalTase 5; beta-3-Gx-T5; beta3Gal-T5; GLCT5;
Species Homo sapiens
Ensembl Protein ENSP00000369994
InnateDB Gene IDBG-3693 (B3GALT5)
Protein Structure
UniProt Annotation
Function Catalyzes the transfer of Gal to GlcNAc-based acceptors with a preference for the core3 O-linked glycan GlcNAc(beta1,3)GalNAc structure. Can use glycolipid LC3Cer as an efficient acceptor.
Subcellular Localization Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed in stomach, jejunum, colon, pancreas, small intestine, testis and gastrointestinal and pancreatic cancer cell lines. Hardly detected in lung, liver, adrenal gland and peripheral blood leukocytes.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0008378 galactosyltransferase activity
GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity
Biological Process
GO:0006486 protein glycosylation
Cellular Component
GO:0000139 Golgi membrane
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR002659 Glycosyl transferase, family 31
IPR029044 Nucleotide-diphospho-sugar transferases
PFAM PF01762
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y2C3
PhosphoSite PhosphoSite-Q9Y2C3
TrEMBL
UniProt Splice Variant
Entrez Gene 10317
UniGene Hs.733638
RefSeq XP_005260969
HUGO HGNC:920
OMIM 604066
CCDS CCDS13667
HPRD 06818
IMGT
EMBL AB020337 AB041413 AB041416 AF145784 AJ006078 AK292951 AL163280 AY372061 BC104862 BC104864 CH471079
GenPept AAF07880 AAI04863 AAI04865 AAR08910 BAA77664 BAA94498 BAA94501 BAF85640 CAB90446 CAB91547 EAX09629 EAX09630 EAX09631 EAX09632

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca