Version 5.4
Homo sapiens Gene: B3GALT5
Summary
InnateDB Gene IDBG-3693.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol B3GALT5
Gene Name UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5
Synonyms B3GalT-V; B3GalTx; B3T5; beta-1,3-GalTase 5; beta-3-Gx-T5; beta3Gal-T5; GLCT5
Species Homo sapiens
Ensembl Gene ENSG00000183778
Encoded Proteins
IDBP-3695
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5
IDBP-3697
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5
IDBP-3699
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5
IDBP-232403
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5
IDBP-808142
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine). The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalT proteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereas beta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during embryogenesis. By sequence similarity, the beta3GalT genes fall into at least two groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3, beta3GalT5). This gene encodes the most probable candidate for synthesis of the type 1 Lewis antigens which are frequently found to be elevated in gastrointestinal and pancreatic cancers. The encoded protein is inactive with N-linked glycoproteins and functions in mucin glycosylation. Alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2012]
This gene encodes a member of a family of membrane-bound glycoproteins. The encoded protein may synthesize type 1 Lewis antigens, which are elevated in gastrointestinal and pancreatic cancers. Alternatively spliced transcript variants have been observed for this gene, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 21:39556442-39673137
Strand Forward strand
Band q22.2
Transcripts
ENST00000380620 ENSP00000369994
ENST00000380618 ENSP00000369992
ENST00000343118 ENSP00000343318
ENST00000398714 ENSP00000381699
ENST00000475838
ENST00000615480 ENSP00000480285
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0008378 galactosyltransferase activity
GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity
Biological Process
GO:0006486 protein glycosylation
Cellular Component
GO:0000139 Golgi membrane
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000074892
View Gene Order
ENSBTAG00000023407
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00601
Glycosphingolipid biosynthesis pathway
hsa00603
Glycosphingolipid biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.733638
RefSeq NM_001278650 NM_006057 NM_033170 NM_033171 NM_033172 XM_005260912
HUGO
OMIM
CCDS CCDS13667 CCDS74795
HPRD 06818
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca