Version 5.4
Homo sapiens Protein: MUC7
Summary
InnateDB Protein IDBP-369698.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MUC7
Protein Name mucin 7, secreted
Synonyms MG2;
Species Homo sapiens
Ensembl Protein ENSP00000407422
InnateDB Gene IDBG-22504 (MUC7)
Protein Structure
UniProt Annotation
Function May function in a protective capacity by promoting the clearance of bacteria in the oral cavity and aiding in mastication, speech, and swallowing. Binds P.aeruginosa pili. {ECO:0000269PubMed:11378823, ECO:0000269PubMed:8104046}.
Subcellular Localization Secreted {ECO:0000269PubMed:7690757}.
Disease Associations Asthma (ASTHMA) [MIM:600807]: The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with wheezing due to spasmodic contraction of the bronchi. {ECO:0000269PubMed:11378823}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
Tissue Specificity Expressed in salivary gland tissues and only in those that contain mucous acinar cells (e.g. sublingual and submandibular glands) and not in salivary glands containing only serous acinar cells (e.g. parotid gland). {ECO:0000269PubMed:1445223, ECO:0000269PubMed:7690757}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0016266 O-glycan processing
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005796 Golgi lumen
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TAX7
PhosphoSite PhosphoSite-
TrEMBL D6RHX1
UniProt Splice Variant
Entrez Gene 4589
UniGene Hs.631946
RefSeq NP_001138478
HUGO HGNC:7518
OMIM 158375
CCDS CCDS3541
HPRD 11759
IMGT
EMBL AC106884 AC108518 BC025688
GenPept AAH25688

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca