Homo sapiens Gene: MUC7
Summary
InnateDB Gene IDBG-22504.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MUC7
Gene Name mucin 7, secreted
Synonyms MG2;
Species Homo sapiens
Ensembl Gene ENSG00000171195
Encoded Proteins
mucin 7, secreted
mucin 7, secreted
mucin 7, secreted
mucin 7, secreted
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a small salivary mucin, which is thought to play a role in facilitating the clearance of bacteria in the oral cavity and to aid in mastication, speech, and swallowing. The central domain of this glycoprotein contains tandem repeats, each composed of 23 amino acids. The most common allele contains 6 repeats, and some alleles may be associated with susceptibility to asthma. Alternatively spliced transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene.[provided by RefSeq, Feb 2009]
This gene encodes a small salivary mucin, which is thought to play a role in facilitating the clearance of bacteria in the oral cavity and to aid in mastication, speech, and swallowing. The central domain of this glycoprotein contains tandem repeats, each composed of 23 amino acids. This antimicrobial protein has antibacterial and antifungal activity. The most common allele contains 6 repeats, and some alleles may be associated with susceptibility to asthma. Alternatively spliced transcript variants with different 5\' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Oct 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:70430492-70482997
Strand Forward strand
Band q13.3
Transcripts
ENST00000304887 ENSP00000302021
ENST00000413702 ENSP00000407422
ENST00000456088 ENSP00000400585
ENST00000515308
ENST00000505411 ENSP00000427594
ENST00000504482
ENST00000514512
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0016266 O-glycan processing
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005796 Golgi lumen
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Post-translational protein modification pathway
O-linked glycosylation of mucins pathway
O-linked glycosylation pathway
Metabolism of proteins pathway
Termination of O-glycan biosynthesis pathway
KEGG
Salivary secretion pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.631946
RefSeq NM_001145006 NM_001145007 NM_152291
HUGO
OMIM
CCDS CCDS3541
HPRD 11759
IMGT
EMBL
GenPept
RNA Seq Atlas