InnateDB Protein
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IDBP-369700.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MUC7
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Protein Name
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mucin 7, secreted
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Synonyms
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MG2;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000400585
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InnateDB Gene
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IDBG-22504 (MUC7)
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Protein Structure
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Function |
May function in a protective capacity by promoting the clearance of bacteria in the oral cavity and aiding in mastication, speech, and swallowing. Binds P.aeruginosa pili. {ECO:0000269PubMed:11378823, ECO:0000269PubMed:8104046}.
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Subcellular Localization |
Secreted {ECO:0000269PubMed:7690757}.
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Disease Associations |
Asthma (ASTHMA) [MIM:600807]: The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with wheezing due to spasmodic contraction of the bronchi. {ECO:0000269PubMed:11378823}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
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Tissue Specificity |
Expressed in salivary gland tissues and only in those that contain mucous acinar cells (e.g. sublingual and submandibular glands) and not in salivary glands containing only serous acinar cells (e.g. parotid gland). {ECO:0000269PubMed:1445223, ECO:0000269PubMed:7690757}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8TAX7
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PhosphoSite |
PhosphoSite-
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TrEMBL |
D6RHX1
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UniProt Splice Variant |
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Entrez Gene |
4589
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UniGene |
Hs.631946
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RefSeq |
NP_001138479
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HUGO |
HGNC:7518
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OMIM |
158375
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CCDS |
CCDS3541
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HPRD |
11759
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IMGT |
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EMBL |
AC106884
AC108518
BC025688
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GenPept |
AAH25688
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