InnateDB Protein
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IDBP-371374.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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WAC
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Protein Name
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WW domain containing adaptor with coiled-coil
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000415727
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InnateDB Gene
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IDBG-65590 (WAC)
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Protein Structure
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Function |
Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription. Regulates the cell-cycle checkpoint activation in response to DNA damage. Positive regulator of amino acid starvation-induced autophagy. May negatively regulate the ubiquitin proteasome pathway. {ECO:0000269PubMed:21329877, ECO:0000269PubMed:22354037}.
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Subcellular Localization |
Nucleus speckle {ECO:0000250}. Nucleus {ECO:0000269PubMed:21329877}. Note=In distinct nuclear speckles. Colocalizes with pre-mRNA processing complexes (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
23
[view]
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Protein-Protein |
23
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
GO:0006351
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transcription, DNA-templated
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GO:0006974
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cellular response to DNA damage stimulus
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GO:0010390
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histone monoubiquitination
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GO:0016239
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positive regulation of macroautophagy
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GO:0032435
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negative regulation of proteasomal ubiquitin-dependent protein catabolic process
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GO:0044783
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G1 DNA damage checkpoint
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GO:0045893
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positive regulation of transcription, DNA-templated
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GO:0071894
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histone H2B conserved C-terminal lysine ubiquitination
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Cellular Component |
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PDB ID |
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InterPro |
IPR001202
WW domain
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PFAM |
PF00397
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PRINTS |
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PIRSF |
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SMART |
SM00456
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TIGRFAMs |
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Modification |
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SwissProt |
Q9BTA9
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PhosphoSite |
PhosphoSite-Q9BTA9
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TrEMBL |
J3QTA0
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UniProt Splice Variant |
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Entrez Gene |
51322
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UniGene |
Hs.743224
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RefSeq |
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HUGO |
HGNC:17327
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OMIM |
615049
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CCDS |
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HPRD |
18291
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IMGT |
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EMBL |
AB058747
AK055852
AK223600
AK290174
AL161936
AL358234
AL713727
BC004258
BC010356
CH471072
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GenPept |
AAH04258
AAH10356
BAB47473
BAB71029
BAD97320
BAF82863
CAD28517
CAH70766
CAH70767
CAH70768
CAI40921
CAI40922
CAI40923
CAI40924
EAW86032
EAW86035
EAW86037
EAW86039
EAW86040
EAW86042
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