Version 5.4
Homo sapiens Gene: WAC
Summary
InnateDB Gene IDBG-65590.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WAC
Gene Name WW domain containing adaptor with coiled-coil
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000095787
Encoded Proteins
IDBP-65592
WW domain containing adaptor with coiled-coil
IDBP-65594
WW domain containing adaptor with coiled-coil
IDBP-65596
WW domain containing adaptor with coiled-coil
IDBP-65600
WW domain containing adaptor with coiled-coil
IDBP-371352
WW domain containing adaptor with coiled-coil
IDBP-371356
WW domain containing adaptor with coiled-coil
IDBP-371358
WW domain containing adaptor with coiled-coil
IDBP-371362
WW domain containing adaptor with coiled-coil
IDBP-371365
WW domain containing adaptor with coiled-coil
IDBP-371366
WW domain containing adaptor with coiled-coil
IDBP-371374
WW domain containing adaptor with coiled-coil
IDBP-602556
WW domain containing adaptor with coiled-coil
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene contains a WW domain, which is a protein module found in a wide range of signaling proteins. This domain mediates protein-protein interactions and binds proteins containing short linear peptide motifs that are proline-rich or contain at least one proline. This gene product shares 94% sequence identity with the WAC protein in mouse, however, its exact function is not known. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:28532493-28623112
Strand Forward strand
Band p12.1
Transcripts
ENST00000375664 ENSP00000364816
ENST00000375646 ENSP00000364797
ENST00000354911 ENSP00000346986
ENST00000345541
ENST00000347934 ENSP00000311106
ENST00000428935 ENSP00000399706
ENST00000420266 ENSP00000404758
ENST00000424454 ENSP00000404125
ENST00000442148 ENSP00000400848
ENST00000448193 ENSP00000395008
ENST00000414108 ENSP00000415645
ENST00000439676 ENSP00000415727
ENST00000472862
ENST00000476046
ENST00000495268
ENST00000480474
ENST00000526722 ENSP00000434903
ENST00000528491
ENST00000532233
ENST00000530865
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 23 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000993 RNA polymerase II core binding
GO:0003682 chromatin binding
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006974 cellular response to DNA damage stimulus
GO:0010390 histone monoubiquitination
GO:0016239 positive regulation of macroautophagy
GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0044783 G1 DNA damage checkpoint
GO:0045893 positive regulation of transcription, DNA-templated
GO:0071894 histone H2B conserved C-terminal lysine ubiquitination
Cellular Component
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0016607 nuclear speck
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024283
View Gene Order
ENSBTAG00000018263
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.740725 Hs.743224
RefSeq NM_016628 NM_100264 NM_100486 XM_005252457 XM_005252459
HUGO
OMIM
CCDS CCDS7159 CCDS7160 CCDS7161
HPRD 18291
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca