InnateDB Protein
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IDBP-371568.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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LTB
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Protein Name
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lymphotoxin beta (TNF superfamily, member 3)
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Synonyms
|
p33; TNFC; TNFSF3;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000416113
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InnateDB Gene
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IDBG-302504 (LTB)
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Protein Structure
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|
Function |
Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional.
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Subcellular Localization |
Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Spleen and thymus.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
4
[view]
|
Protein-Protein |
4
[view]
|
Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
|
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Predicted by orthology |
Total |
3 [view]
|
|
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002961
Lymphotoxin-beta
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PFAM |
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PRINTS |
PR01237
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q06643
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PhosphoSite |
PhosphoSite-
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TrEMBL |
|
UniProt Splice Variant |
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Entrez Gene |
4050
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UniGene |
|
RefSeq |
NP_033666
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HUGO |
HGNC:6711
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OMIM |
600978
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CCDS |
CCDS4704
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HPRD |
02987
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IMGT |
|
EMBL |
AF129756
AK312210
AY070219
AY216497
BA000025
BC069330
BC093783
CH471081
L11015
L11016
U79029
U89922
Y14768
|
GenPept |
AAA36191
AAA99888
AAB37342
AAC51769
AAD18089
AAH69330
AAH93783
AAL49954
AAL49955
AAO21134
BAB63395
BAG35143
CAA75069
EAX03425
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