InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CD44

Summary

InnateDB Protein

IDBP-371588.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD44

Protein Name

CD44 molecule (Indian blood group)

Synonyms

CDW44; CSPG8; ECMR-III; HCELL; HUTCH-I; IN; LHR; MC56; MDU2; MDU3; MIC4; Pgp1;

Species

Homo sapiens

Ensembl Protein

ENSP00000392331

InnateDB Gene

IDBG-39556 (CD44)

Protein Structure

UniProt Annotation

Function

Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. {ECO:0000269PubMed:16541107}.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein. Note=Colocalizes with actin in membrane protrusions at wounding edges. {ECO:0000250}.

Disease Associations

Tissue Specificity

Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 60 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	60 [view]
Protein-Protein	56 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004415	hyalurononglucosaminidase activity
GO:0004888	transmembrane signaling receptor activity
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0005540	hyaluronic acid binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0007155	cell adhesion
GO:0007160	cell-matrix adhesion
GO:0007596	blood coagulation
GO:0016337	single organismal cell-cell adhesion
GO:0019221	cytokine-mediated signaling pathway
GO:0022617	extracellular matrix disassembly
GO:0030198	extracellular matrix organization
GO:0030203	glycosaminoglycan metabolic process
GO:0030212	hyaluronan metabolic process
GO:0030214	hyaluronan catabolic process
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0034116	positive regulation of heterotypic cell-cell adhesion
GO:0043066	negative regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0044281	small molecule metabolic process
GO:0044344	cellular response to fibroblast growth factor stimulus
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050900	leukocyte migration
GO:0051216	cartilage development
GO:0060333	interferon-gamma-mediated signaling pathway
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0070487	monocyte aggregation
GO:1900625	positive regulation of monocyte aggregation
GO:1902166	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

Cellular Component

GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0070062	extracellular vesicular exosome