Version 5.4
Homo sapiens Gene: CD44
Summary
InnateDB Gene IDBG-39556.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD44
Gene Name CD44 molecule (Indian blood group)
Synonyms CDW44; CSPG8; ECMR-III; HCELL; HUTCH-I; IN; LHR; MC56; MDU2; MDU3; MIC4; Pgp1
Species Homo sapiens
Ensembl Gene ENSG00000026508
Encoded Proteins
IDBP-39558
CD44 molecule (Indian blood group)
IDBP-39560
CD44 molecule (Indian blood group)
IDBP-39562
CD44 molecule (Indian blood group)
IDBP-39564
CD44 molecule (Indian blood group)
IDBP-39566
CD44 molecule (Indian blood group)
IDBP-371570
CD44 molecule (Indian blood group)
IDBP-371576
CD44 molecule (Indian blood group)
IDBP-371583
CD44 molecule (Indian blood group)
IDBP-371588
CD44 molecule (Indian blood group)
IDBP-371597
CD44 molecule (Indian blood group)
IDBP-371601
CD44 molecule (Indian blood group)
IDBP-595050
CD44 molecule (Indian blood group)
IDBP-590993
CD44 molecule (Indian blood group)
IDBP-591932
CD44 molecule (Indian blood group)
IDBP-585748
CD44 molecule (Indian blood group)
IDBP-590343
CD44 molecule (Indian blood group)
IDBP-600690
CD44 molecule (Indian blood group)
IDBP-592572
CD44 molecule (Indian blood group)
IDBP-597914
CD44 molecule (Indian blood group)
IDBP-600650
CD44 molecule (Indian blood group)
IDBP-596274
CD44 molecule (Indian blood group)
IDBP-600269
CD44 molecule (Indian blood group)
IDBP-603659
CD44 molecule (Indian blood group)
IDBP-597787
CD44 molecule (Indian blood group)
IDBP-600166
CD44 molecule (Indian blood group)
IDBP-597062
CD44 molecule (Indian blood group)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:35138870-35232402
Strand Forward strand
Band p13
Transcripts
ENST00000278385 ENSP00000278385
ENST00000279452 ENSP00000279452
ENST00000352818 ENSP00000309732
ENST00000263398 ENSP00000263398
ENST00000278386 ENSP00000278386
ENST00000425428 ENSP00000395953
ENST00000434472 ENSP00000404447
ENST00000428726 ENSP00000398632
ENST00000433892 ENSP00000392331
ENST00000415148 ENSP00000389830
ENST00000442151 ENSP00000398099
ENST00000526025 ENSP00000435377
ENST00000528086
ENST00000525211 ENSP00000432405
ENST00000526669 ENSP00000432704
ENST00000526000 ENSP00000434465
ENST00000527889 ENSP00000434530
ENST00000531118
ENST00000528455 ENSP00000432718
ENST00000531873 ENSP00000433189
ENST00000525209
ENST00000531110 ENSP00000436549
ENST00000525685 ENSP00000436623
ENST00000534296
ENST00000525688 ENSP00000436980
ENST00000533222 ENSP00000435321
ENST00000525241
ENST00000524922 ENSP00000436451
ENST00000528922
ENST00000525348
ENST00000526553 ENSP00000434418
ENST00000534082
ENST00000525293
ENST00000528672 ENSP00000431860
ENST00000532339
ENST00000527326
ENST00000531141
ENST00000525469 ENSP00000434920
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 60 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 60 [view]
Protein-Protein 56 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004415 hyalurononglucosaminidase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding
GO:0005518 collagen binding
GO:0005540 hyaluronic acid binding
Biological Process
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0002246 wound healing involved in inflammatory response
GO:0005975 carbohydrate metabolic process
GO:0007155 cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007596 blood coagulation
GO:0010628 positive regulation of gene expression
GO:0016055 Wnt signaling pathway
GO:0016337 single organismal cell-cell adhesion
GO:0019221 cytokine-mediated signaling pathway
GO:0022617 extracellular matrix disassembly
GO:0030198 extracellular matrix organization
GO:0030203 glycosaminoglycan metabolic process
GO:0030212 hyaluronan metabolic process
GO:0030214 hyaluronan catabolic process
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034116 positive regulation of heterotypic cell-cell adhesion
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0044281 small molecule metabolic process
GO:0044344 cellular response to fibroblast growth factor stimulus
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050900 leukocyte migration
GO:0051216 cartilage development
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060442 branching involved in prostate gland morphogenesis
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070487 monocyte aggregation
GO:1900625 positive regulation of monocyte aggregation
GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
Cellular Component
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000005087
View Gene Order
ENSBTAG00000011578
Not yet available
Pathways
NETPATH
NetPath_7
TGF_beta_Receptor pathway
NetPath_22
Leptin pathway
REACTOME
REACT_25078
Interferon gamma signaling pathway
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_13552
Integrin cell surface interactions pathway
REACT_120996
Hyaluronan uptake and degradation pathway
REACT_147853
Mucopolysaccharidoses pathway
REACT_200783
Myoclonic epilepsy of Lafora pathway
REACT_118779
Extracellular matrix organization pathway
REACT_267711
Defective B4GALT7 causes EDS, progeroid type pathway
REACT_267713
Defective CHST6 causes MCDC1 pathway
REACT_147719
MPS VI - Maroteaux-Lamy syndrome pathway
REACT_267645
Defective PAPSS2 causes SEMD-PA pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_474
Metabolism of carbohydrates pathway
REACT_118572
Degradation of the extracellular matrix pathway
REACT_147749
MPS IIID - Sanfilippo syndrome D pathway
REACT_267662
Defective SLC26A2 causes chondrodysplasias pathway
REACT_25229
Interferon Signaling pathway
REACT_147739
MPS IX - Natowicz syndrome pathway
REACT_267674
Defective EXT1 causes exostoses 1, TRPS2 and CHDS pathway
REACT_267642
Defective CHST14 causes EDS, musculocontractural type pathway
REACT_6900
Immune System pathway
REACT_147798
MPS IV - Morquio syndrome B pathway
REACT_267659
Defective B3GAT3 causes JDSSDHD pathway
REACT_267708
Defective CHST3 causes SEDCJD pathway
REACT_147825
MPS IV - Morquio syndrome A pathway
REACT_267654
Defective EXT2 causes exostoses 2 pathway
REACT_267707
Diseases associated with glycosaminoglycan metabolism pathway
REACT_147734
MPS II - Hunter syndrome pathway
REACT_267635
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) pathway
REACT_121315
Glycosaminoglycan metabolism pathway
REACT_267705
Diseases of glycosylation pathway
REACT_147759
MPS VII - Sly syndrome pathway
REACT_267682
Defective CHSY1 causes TPBS pathway
REACT_111217
Metabolism pathway
REACT_147857
MPS I - Hurler syndrome pathway
REACT_147753
MPS IIIA - Sanfilippo syndrome A pathway
REACT_121083
Hyaluronan metabolism pathway
REACT_147860
MPS IIIC - Sanfilippo syndrome C pathway
REACT_116125
Disease pathway
REACT_200833
Glycogen storage diseases pathway
REACT_604
Hemostasis pathway
REACT_147788
MPS IIIB - Sanfilippo syndrome B pathway
KEGG
hsa04640
Hematopoietic cell lineage pathway
hsa04512
ECM-receptor interaction pathway
hsa05131
Shigellosis pathway
INOH
INOH website
Integrin signaling pathway pathway
INOH website
Wnt signaling pathway pathway
PID NCI
avb3_opn_pathway
Osteopontin-mediated events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.626357 Hs.662037 Hs.733491
RefSeq NM_000610 NM_001001389 NM_001001390 NM_001001391 NM_001001392 NM_001202555 NM_001202556 NM_001202557
HUGO
OMIM
CCDS CCDS31455 CCDS31456 CCDS31457 CCDS31458 CCDS55754 CCDS55755 CCDS7897
HPRD 00115
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca