Homo sapiens Gene: CD44
InnateDB Gene IDBG-39556.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD44
Gene Name CD44 molecule (Indian blood group)
Synonyms CDW44; CSPG8; ECMR-III; HCELL; HUTCH-I; IN; LHR; MC56; MDU2; MDU3; MIC4; Pgp1
Species Homo sapiens
Ensembl Gene ENSG00000026508
Encoded Proteins
CD44 molecule (Indian blood group)
CD44 molecule (Indian blood group)
CD44 molecule (Indian blood group)
CD44 molecule (Indian blood group)
CD44 molecule (Indian blood group)
CD44 molecule (Indian blood group)
CD44 molecule (Indian blood group)
CD44 molecule (Indian blood group)
CD44 molecule (Indian blood group)
CD44 molecule (Indian blood group)
CD44 molecule (Indian blood group)
CD44 molecule (Indian blood group)
CD44 molecule (Indian blood group)
CD44 molecule (Indian blood group)
CD44 molecule (Indian blood group)
CD44 molecule (Indian blood group)
CD44 molecule (Indian blood group)
CD44 molecule (Indian blood group)
CD44 molecule (Indian blood group)
CD44 molecule (Indian blood group)
CD44 molecule (Indian blood group)
CD44 molecule (Indian blood group)
CD44 molecule (Indian blood group)
CD44 molecule (Indian blood group)
CD44 molecule (Indian blood group)
CD44 molecule (Indian blood group)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:35138870-35232402
Strand Forward strand
Band p13
ENST00000278385 ENSP00000278385
ENST00000279452 ENSP00000279452
ENST00000352818 ENSP00000309732
ENST00000263398 ENSP00000263398
ENST00000278386 ENSP00000278386
ENST00000425428 ENSP00000395953
ENST00000434472 ENSP00000404447
ENST00000428726 ENSP00000398632
ENST00000433892 ENSP00000392331
ENST00000415148 ENSP00000389830
ENST00000442151 ENSP00000398099
ENST00000526025 ENSP00000435377
ENST00000525211 ENSP00000432405
ENST00000526669 ENSP00000432704
ENST00000526000 ENSP00000434465
ENST00000527889 ENSP00000434530
ENST00000528455 ENSP00000432718
ENST00000531873 ENSP00000433189
ENST00000531110 ENSP00000436549
ENST00000525685 ENSP00000436623
ENST00000525688 ENSP00000436980
ENST00000533222 ENSP00000435321
ENST00000524922 ENSP00000436451
ENST00000526553 ENSP00000434418
ENST00000528672 ENSP00000431860
ENST00000525469 ENSP00000434920
Number of Interactions This gene and/or its encoded proteins are associated with 60 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 60 [view]
Protein-Protein 56 [view]
Protein-DNA 4 [view]
Protein-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004415 hyalurononglucosaminidase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding
GO:0005518 collagen binding
GO:0005540 hyaluronic acid binding
Biological Process
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0002246 wound healing involved in inflammatory response
GO:0005975 carbohydrate metabolic process
GO:0007155 cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007596 blood coagulation
GO:0010628 positive regulation of gene expression
GO:0016055 Wnt signaling pathway
GO:0016337 single organismal cell-cell adhesion
GO:0019221 cytokine-mediated signaling pathway
GO:0022617 extracellular matrix disassembly
GO:0030198 extracellular matrix organization
GO:0030203 glycosaminoglycan metabolic process
GO:0030212 hyaluronan metabolic process
GO:0030214 hyaluronan catabolic process
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034116 positive regulation of heterotypic cell-cell adhesion
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0044281 small molecule metabolic process
GO:0044344 cellular response to fibroblast growth factor stimulus
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050900 leukocyte migration
GO:0051216 cartilage development
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060442 branching involved in prostate gland morphogenesis
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070487 monocyte aggregation
GO:1900625 positive regulation of monocyte aggregation
GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
Cellular Component
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0070062 extracellular vesicular exosome
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
TGF_beta_Receptor pathway
Leptin pathway
Interferon gamma signaling pathway
Cell surface interactions at the vascular wall pathway
Integrin cell surface interactions pathway
Hyaluronan uptake and degradation pathway
Mucopolysaccharidoses pathway
Myoclonic epilepsy of Lafora pathway
Extracellular matrix organization pathway
Defective B4GALT7 causes EDS, progeroid type pathway
Defective CHST6 causes MCDC1 pathway
MPS VI - Maroteaux-Lamy syndrome pathway
Defective PAPSS2 causes SEMD-PA pathway
Cytokine Signaling in Immune system pathway
Metabolism of carbohydrates pathway
Degradation of the extracellular matrix pathway
MPS IIID - Sanfilippo syndrome D pathway
Defective SLC26A2 causes chondrodysplasias pathway
Interferon Signaling pathway
MPS IX - Natowicz syndrome pathway
Defective EXT1 causes exostoses 1, TRPS2 and CHDS pathway
Defective CHST14 causes EDS, musculocontractural type pathway
Immune System pathway
MPS IV - Morquio syndrome B pathway
Defective B3GAT3 causes JDSSDHD pathway
Defective CHST3 causes SEDCJD pathway
MPS IV - Morquio syndrome A pathway
Defective EXT2 causes exostoses 2 pathway
Diseases associated with glycosaminoglycan metabolism pathway
MPS II - Hunter syndrome pathway
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) pathway
Glycosaminoglycan metabolism pathway
Diseases of glycosylation pathway
MPS VII - Sly syndrome pathway
Defective CHSY1 causes TPBS pathway
Metabolism pathway
MPS I - Hurler syndrome pathway
MPS IIIA - Sanfilippo syndrome A pathway
Hyaluronan metabolism pathway
MPS IIIC - Sanfilippo syndrome C pathway
Disease pathway
Glycogen storage diseases pathway
Hemostasis pathway
MPS IIIB - Sanfilippo syndrome B pathway
Hematopoietic cell lineage pathway
ECM-receptor interaction pathway
Shigellosis pathway
Integrin signaling pathway pathway
Wnt signaling pathway pathway
Osteopontin-mediated events
UniProt Splice Variant
Entrez Gene
UniGene Hs.626357 Hs.662037 Hs.733491
RefSeq NM_000610 NM_001001389 NM_001001390 NM_001001391 NM_001001392 NM_001202555 NM_001202556 NM_001202557
CCDS CCDS31455 CCDS31456 CCDS31457 CCDS31458 CCDS55754 CCDS55755 CCDS7897
HPRD 00115
RNA Seq Atlas