Version 5.4
Homo sapiens Protein: NECAB3
Summary
InnateDB Protein IDBP-371924.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NECAB3
Protein Name N-terminal EF-hand calcium binding protein 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000392064
InnateDB Gene IDBG-66925 (NECAB3)
Protein Structure
UniProt Annotation
Function Inhibits the interaction of APBA2 with beta-amyloid precursor protein (APP), and hence allows formation of beta- amyloid. {ECO:0000269PubMed:10833507}.
Subcellular Localization Golgi apparatus {ECO:0000269PubMed:10833507, ECO:0000269PubMed:14697346}.
Disease Associations
Tissue Specificity Strongly expressed in heart and skeletal muscle, moderately in brain and pancreas. {ECO:0000269PubMed:10833507, ECO:0000269PubMed:12044471}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
Biological Process
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR002048 EF-hand domain
IPR011008 Dimeric alpha-beta barrel
PFAM PF00036
PF13202
PF13405
PRINTS
PIRSF
SMART SM00054
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-Q96P71
TrEMBL X6RCW6
UniProt Splice Variant
Entrez Gene 63941
UniGene Hs.629982
RefSeq
HUGO HGNC:15851
OMIM 612478
CCDS
HPRD 07168
IMGT
EMBL AL121906
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca