Homo sapiens Gene: NECAB3
Summary
InnateDB Gene IDBG-66925.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NECAB3
Gene Name N-terminal EF-hand calcium binding protein 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000125967
Encoded Proteins
N-terminal EF-hand calcium binding protein 3
N-terminal EF-hand calcium binding protein 3
N-terminal EF-hand calcium binding protein 3
N-terminal EF-hand calcium binding protein 3
N-terminal EF-hand calcium binding protein 3
N-terminal EF-hand calcium binding protein 3
N-terminal EF-hand calcium binding protein 3
N-terminal EF-hand calcium binding protein 3
N-terminal EF-hand calcium binding protein 3
N-terminal EF-hand calcium binding protein 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene interacts with the amino-terminal domain of the neuron-specific X11-like protein (X11L), inhibits the association of X11L with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by X11L. This protein, together with X11L, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. The protein is phosphorylated by NIMA-related expressed kinase 2, and localizes to the Golgi apparatus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:33657087-33674463
Strand Reverse strand
Band q11.22
Transcripts
ENST00000375238 ENSP00000364386
ENST00000246190 ENSP00000246190
ENST00000439478 ENSP00000392064
ENST00000477778
ENST00000488489 ENSP00000475938
ENST00000483813
ENST00000485399 ENSP00000475369
ENST00000485976
ENST00000478237
ENST00000494174
ENST00000463246
ENST00000480994 ENSP00000475834
ENST00000498353
ENST00000493590 ENSP00000475755
ENST00000473892 ENSP00000476165
ENST00000484824
ENST00000606525
ENST00000606690 ENSP00000475420
ENST00000607805 ENSP00000476044
ENST00000606106
ENST00000606699
ENST00000607055
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0009306 protein secretion
GO:0019538 protein metabolic process
GO:0042984 regulation of amyloid precursor protein biosynthetic process
Cellular Component
GO:0000137 Golgi cis cisterna
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_031231 NM_031232
HUGO
OMIM
CCDS CCDS42866 CCDS42867
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas