Version 5.4
Homo sapiens Protein: INSL3
Summary
InnateDB Protein IDBP-37205.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol INSL3
Protein Name insulin-like 3 (Leydig cell)
Synonyms ley-I-L; RLF; RLNL;
Species Homo sapiens
Ensembl Protein ENSP00000321724
InnateDB Gene IDBG-405522 (INSL3)
Protein Structure
UniProt Annotation
Function Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor.
Subcellular Localization Secreted.
Disease Associations Cryptorchidism (CRYPTO) [MIM:219050]: One of the most frequent congenital abnormalities in humans, involving 2-5% of male births. Cryptorchidism is associated with increased risk of infertility and testicular cancer. {ECO:0000269PubMed:11095425, ECO:0000269PubMed:11746019, ECO:0000269PubMed:12601553}. Note=The disease may be caused by mutations affecting the gene represented in this entry.
Tissue Specificity Expressed in prenatal and postnatal Leydig cells. Found as well in the corpus luteum, trophoblast, fetal membranes and breast. {ECO:0000269PubMed:7852540}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0005102 receptor binding
GO:0005158 insulin receptor binding
GO:0005179 hormone activity
Biological Process
GO:0007267 cell-cell signaling
GO:0007283 spermatogenesis
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID
InterPro IPR016179 Insulin-like
PFAM PF00049
PRINTS
PIRSF
SMART SM00078
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P51460
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 3640
UniGene Hs.741876
RefSeq NP_005534
HUGO HGNC:6086
OMIM 146738
CCDS CCDS12365
HPRD 08854
IMGT
EMBL AC005952 AC007201 AK302780 AY082014 BC032810 BC053345 BC071706 BC106721 BC106722 CH471106 S72482 X73637
GenPept AAB31371 AAD22740 AAH32810 AAH53345 AAH71706 AAI06722 AAI06723 AAL92559 BAG63984 CAA52017 EAW84635

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca