Homo sapiens Gene: INSL3
Summary
InnateDB Gene IDBG-405522.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol INSL3
Gene Name insulin-like 3 (Leydig cell)
Synonyms ley-I-L; RLF; RLNL;
Species Homo sapiens
Ensembl Gene ENSG00000248099
Encoded Proteins
insulin-like 3 (Leydig cell)
insulin-like 3 (Leydig cell)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the insulin-like hormone superfamily. The encoded protein is mainly produced in gonadal tissues. Studies of the mouse counterpart suggest that this gene may be involved in the development of urogenital tract and female fertility. This protein may also act as a hormone to regulate growth and differentiation of gubernaculum, and thus mediating intra-abdominal testicular descent. Mutations in this gene may lead to cryptorchidism. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:17816512-17821574
Strand Reverse strand
Band p13.11
Transcripts
ENST00000379695 ENSP00000369017
ENST00000317306 ENSP00000321724
ENST00000598577 ENSP00000469309
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001664 G-protein coupled receptor binding
GO:0002020 protease binding
GO:0005102 receptor binding
GO:0005158 insulin receptor binding
GO:0005179 hormone activity
Biological Process
GO:0001556 oocyte maturation
GO:0001701 in utero embryonic development
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007267 cell-cell signaling
GO:0007283 spermatogenesis
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0008584 male gonad development
GO:0030819 positive regulation of cAMP biosynthetic process
GO:0043066 negative regulation of apoptotic process
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
G alpha (s) signalling events pathway
Class A/1 (Rhodopsin-like receptors) pathway
Relaxin receptors pathway
Signaling by GPCR pathway
Peptide ligand-binding receptors pathway
Signal Transduction pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 3640
UniGene Hs.37062 Hs.741876
RefSeq NM_001265587 NM_005543
HUGO HGNC:6086
OMIM 146738
CCDS CCDS58655 CCDS12365
HPRD 08854
IMGT
EMBL
GenPept
RNA Seq Atlas 3640