Homo sapiens Protein: SFRP4
InnateDB Protein IDBP-372443.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SFRP4
Protein Name secreted frizzled-related protein 4
Synonyms FRP-4; FRPHE; sFRP-4;
Species Homo sapiens
Ensembl Protein ENSP00000410715
InnateDB Gene IDBG-12815 (SFRP4)
Protein Structure
UniProt Annotation
Function Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 may act as a regulator of adult uterine morphology and function. Increases apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake. {ECO:0000250}.
Subcellular Localization Secreted {ECO:0000269PubMed:19480240}. Note=Cytoplasmic in ovarian tumor cells.
Disease Associations
Tissue Specificity Expressed in mesenchymal cells. Highly expressed in the stroma of proliferative endometrium. Expressed in cardiomyocytes. Shows moderate to strong expression in ovarian tumors with expression increasing as the tumor stage increases. In ovarian tumors, expression levels are inversely correlated with expression of CTNNB1 (at protein level). {ECO:0000269PubMed:10728394, ECO:0000269PubMed:19480240}.
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017147 Wnt-protein binding
GO:0030165 PDZ domain binding
GO:0042813 Wnt-activated receptor activity
Biological Process
GO:0001944 vasculature development
GO:0002092 positive regulation of receptor internalization
GO:0007420 brain development
GO:0008285 negative regulation of cell proliferation
GO:0008406 gonad development
GO:0009725 response to hormone
GO:0010628 positive regulation of gene expression
GO:0016055 Wnt signaling pathway
GO:0022601 menstrual cycle phase
GO:0043065 positive regulation of apoptotic process
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045606 positive regulation of epidermal cell differentiation
GO:0046329 negative regulation of JNK cascade
GO:0046697 decidualization
GO:0055062 phosphate ion homeostasis
GO:0060056 mammary gland involution
GO:0060429 epithelium development
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:1902174 positive regulation of keratinocyte apoptotic process
GO:2000119 negative regulation of sodium-dependent phosphate transport
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0009986 cell surface
Protein Structure and Domains
InterPro IPR001134 Netrin domain
IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
IPR018933 Netrin module, non-TIMP type
IPR020067 Frizzled domain
PFAM PF01759
Post-translational Modifications
SwissProt Q6FHJ7
PhosphoSite PhosphoSite-Q6FHJ7
UniProt Splice Variant
Entrez Gene 6424
UniGene Hs.710782
RefSeq NP_003005
OMIM 606570
HPRD 07357
EMBL AF026692 AK302357 BC047684 BC058911 BT019679 CH236951 CR541731 CR541755 DQ420628
GenPept AAC04617 AAH47684 AAH58911 AAV38485 ABD83351 BAG63683 CAG46532 CAG46555 EAL23981