InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ALDH3A1

Summary

InnateDB Protein

IDBP-372694.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ALDH3A1

Protein Name

aldehyde dehydrogenase 3 family, member A1

Synonyms

ALDH3; ALDHIII;

Species

Homo sapiens

Ensembl Protein

ENSP00000388469

InnateDB Gene

IDBG-35000 (ALDH3A1)

Protein Structure

UniProt Annotation

Function

ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

High levels in stomach, esophagus and lung; low level in the liver and kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	4 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003995	acyl-CoA dehydrogenase activity
GO:0004029	aldehyde dehydrogenase (NAD) activity
GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity
GO:0008106	alcohol dehydrogenase (NADP+) activity
GO:0016491	oxidoreductase activity

Biological Process

GO:0006081	cellular aldehyde metabolic process
GO:0008152	metabolic process
GO:0008218	bioluminescence
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005829	cytosol
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR008670 Acyl-CoA reductase, LuxC
IPR012394 Aldehyde dehydrogenase NAD(P)-dependent
IPR015590 Aldehyde dehydrogenase domain
IPR016161 Aldehyde/histidinol dehydrogenase

PFAM

PF05893
PF00171

PRINTS

PIRSF

PIRSF009414
PIRSF036492

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P30838