InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ALDH3A1

Summary

InnateDB Gene

IDBG-35000.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ALDH3A1

Gene Name

aldehyde dehydrogenase 3 family, member A1

Synonyms

ALDH3; ALDHIII

Species

Homo sapiens

Ensembl Gene

ENSG00000108602

Encoded Proteins

IDBP-35002

aldehyde dehydrogenase 3 family, member A1

IDBP-239313

aldehyde dehydrogenase 3 family, member A1

IDBP-372694

aldehyde dehydrogenase 3 family, member A1

IDBP-372696

aldehyde dehydrogenase 3 family, member A1

IDBP-372708

aldehyde dehydrogenase 3 family, member A1

IDBP-372710

aldehyde dehydrogenase 3 family, member A1

IDBP-759198

IDBP-587286

aldehyde dehydrogenase 3 family, member A1

IDBP-762056

IDBP-758287

IDBP-758331

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. The enzyme encoded by this gene forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. It is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:19737984-19748943

Strand

Reverse strand

Band

p11.2

Transcripts

ENST00000225740	ENSP00000225740
ENST00000395555	ENSP00000378923
ENST00000444455	ENSP00000388469
ENST00000457500	ENSP00000411821
ENST00000439102	ENSP00000389766
ENST00000426645	ENSP00000388369
ENST00000479677
ENST00000487650
ENST00000494157	ENSP00000460482
ENST00000468746	ENSP00000434685
ENST00000485472
ENST00000485231
ENST00000575103
ENST00000570414	ENSP00000460792
ENST00000575860
ENST00000574162	ENSP00000458841
ENST00000573368	ENSP00000461189

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	4 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003995	acyl-CoA dehydrogenase activity
GO:0004028	3-chloroallyl aldehyde dehydrogenase activity
GO:0004029	aldehyde dehydrogenase (NAD) activity
GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity
GO:0008106	alcohol dehydrogenase (NADP+) activity
GO:0016491	oxidoreductase activity
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

Biological Process

GO:0001666	response to hypoxia
GO:0006081	cellular aldehyde metabolic process
GO:0007568	aging
GO:0007584	response to nutrient
GO:0008152	metabolic process
GO:0008218	bioluminescence
GO:0008284	positive regulation of cell proliferation
GO:0014070	response to organic cyclic compound
GO:0042493	response to drug
GO:0051384	response to glucocorticoid
GO:0051591	response to cAMP
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005829	cytosol
GO:0005886	plasma membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000019102

View Gene Order

ENSBTAG00000021113

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa00010

Glycolysis / Gluconeogenesis pathway

hsa00340

Histidine metabolism pathway

hsa00360

Phenylalanine metabolism pathway

hsa00350

Tyrosine metabolism pathway

hsa00410

beta-Alanine metabolism pathway

hsa00980

Metabolism of xenobiotics by cytochrome P450 pathway

hsa00982

Drug metabolism pathway

INOH

INOH website

Phenylalanine degradation pathway

INOH website

Tyrosine metabolism pathway

INOH website

Histidine degradation pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.531682

RefSeq

NM_000691 NM_001135167 NM_001135168

HUGO

OMIM

CCDS

CCDS11212

HPRD

00004

IMGT

EMBL

GenPept

RNA Seq Atlas