InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RPSA

Summary

InnateDB Protein

IDBP-372871.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RPSA

Protein Name

ribosomal protein SA

Synonyms

37LRP; 67LR; E2; E2-1; ICAS; LAMBR; lamR; LAMR1; LBP; LBP/p40; LRP; LRP/LR; NEM/1CHD4; p40; RNE2; RNU108; SA;

Species

Homo sapiens

Ensembl Protein

ENSP00000389351

InnateDB Gene

IDBG-26807 (RPSA)

Protein Structure

UniProt Annotation

Function

Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. {ECO:0000255HAMAP-Rule:MF_03016, ECO:0000269PubMed:15516338, ECO:0000269PubMed:16263087, ECO:0000269PubMed:6300843}.

Subcellular Localization

Cell membrane. Cytoplasm. Nucleus {ECO:0000255HAMAP-Rule:MF_03016}. Note=67LR is found at the surface of the plasma membrane, with its C-terminal laminin- binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus (By similarity). Colocalizes with PPP1R16B in the cell membrane. {ECO:0000255HAMAP-Rule:MF_03016}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 165 experimentally validated interaction(s) in this database.

Experimentally validated
Total	165 [view]
Protein-Protein	165 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003735	structural constituent of ribosome
GO:0005055	laminin receptor activity
GO:0005515	protein binding
GO:0043022	ribosome binding
GO:0043236	laminin binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000028	ribosomal small subunit assembly
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000461	endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006407	rRNA export from nucleus
GO:0006412	translation
GO:0006413	translational initiation
GO:0006414	translational elongation
GO:0006415	translational termination
GO:0006614	SRP-dependent cotranslational protein targeting to membrane
GO:0007155	cell adhesion
GO:0010467	gene expression
GO:0016032	viral process
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0019058	viral life cycle
GO:0019083	viral transcription
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0005886	plasma membrane
GO:0015935	small ribosomal subunit
GO:0016020	membrane
GO:0022627	cytosolic small ribosomal subunit
GO:0030686	90S preribosome
GO:0070062	extracellular vesicular exosome