InnateDB Protein
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IDBP-372871.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RPSA
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Protein Name
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ribosomal protein SA
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Synonyms
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37LRP; 67LR; E2; E2-1; ICAS; LAMBR; lamR; LAMR1; LBP; LBP/p40; LRP; LRP/LR; NEM/1CHD4; p40; RNE2; RNU108; SA;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000389351
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InnateDB Gene
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IDBG-26807 (RPSA)
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Protein Structure
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Function |
Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. {ECO:0000255HAMAP-Rule:MF_03016, ECO:0000269PubMed:15516338, ECO:0000269PubMed:16263087, ECO:0000269PubMed:6300843}.
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Subcellular Localization |
Cell membrane. Cytoplasm. Nucleus {ECO:0000255HAMAP-Rule:MF_03016}. Note=67LR is found at the surface of the plasma membrane, with its C-terminal laminin- binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus (By similarity). Colocalizes with PPP1R16B in the cell membrane. {ECO:0000255HAMAP-Rule:MF_03016}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 165 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
165
[view]
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Protein-Protein |
165
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001865
Ribosomal protein S2
IPR005707
Ribosomal protein S2, eukaryotic/archaeal
IPR023591
Ribosomal protein S2, flavodoxin-like domain
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PFAM |
PF00318
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PRINTS |
PR00395
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P08865
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PhosphoSite |
PhosphoSite-P08865
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
6044
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UniGene |
Hs.731290
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RefSeq |
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HUGO |
HGNC:6502
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OMIM |
180646
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CCDS |
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HPRD |
01038
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IMGT |
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EMBL |
AB007146
AF503367
BC005391
BC008867
BC010418
BC013827
BC034537
BC050688
BC053370
BC062714
BC066941
BC068062
BC070263
BC071693
BC071968
BC071969
BC071970
BC073863
BC107567
BT007219
J03799
M14199
S37431
U36484
U43901
X15005
X61156
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GenPept |
AAA36161
AAA36165
AAB22299
AAC50313
AAC50652
AAH05391
AAH08867
AAH10418
AAH13827
AAH34537
AAH50688
AAH53370
AAH62714
AAH66941
AAH68062
AAH70263
AAH71693
AAH71968
AAH71969
AAH71970
AAH73863
AAI07568
AAM33304
AAP35883
BAA25812
CAA33112
CAA43469
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