InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: INHBA

Summary

InnateDB Protein

IDBP-372911.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

INHBA

Protein Name

inhibin, beta A

Synonyms

EDF; FRP;

Species

Homo sapiens

Ensembl Protein

ENSP00000397197

InnateDB Gene

IDBG-13490 (INHBA)

Protein Structure

UniProt Annotation

Function

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	13 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005179	hormone activity
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0017046	peptide hormone binding
GO:0042802	identical protein binding
GO:0070699	type II activin receptor binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0001541	ovarian follicle development
GO:0001942	hair follicle development
GO:0002244	hematopoietic progenitor cell differentiation
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006952	defense response
GO:0007050	cell cycle arrest
GO:0007166	cell surface receptor signaling pathway
GO:0007267	cell-cell signaling
GO:0007399	nervous system development
GO:0008285	negative regulation of cell proliferation
GO:0008584	male gonad development
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0030154	cell differentiation
GO:0030218	erythrocyte differentiation
GO:0030308	negative regulation of cell growth
GO:0032270	positive regulation of cellular protein metabolic process
GO:0032924	activin receptor signaling pathway
GO:0035987	endodermal cell differentiation
GO:0040007	growth
GO:0042326	negative regulation of phosphorylation
GO:0042476	odontogenesis
GO:0042493	response to drug
GO:0042541	hemoglobin biosynthetic process
GO:0042701	progesterone secretion
GO:0045077	negative regulation of interferon-gamma biosynthetic process
GO:0045578	negative regulation of B cell differentiation
GO:0045648	positive regulation of erythrocyte differentiation
GO:0045650	negative regulation of macrophage differentiation
GO:0045786	negative regulation of cell cycle
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046880	regulation of follicle-stimulating hormone secretion
GO:0046881	positive regulation of follicle-stimulating hormone secretion
GO:0046882	negative regulation of follicle-stimulating hormone secretion
GO:0060021	palate development
GO:0060279	positive regulation of ovulation
GO:0061029	eyelid development in camera-type eye
GO:0097191	extrinsic apoptotic signaling pathway
GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

Cellular Component

GO:0005576	extracellular region
GO:0043509	activin A complex
GO:0043512	inhibin A complex

Protein Structure and Domains

PDB ID

InterPro

IPR000491 Inhibin, beta A subunit
IPR001111 Transforming growth factor-beta, N-terminal
IPR001839 Transforming growth factor-beta, C-terminal
IPR002405 Inhibin, alpha subunit
IPR029034 Cystine-knot cytokine

PFAM

PF00688
PF00019

PRINTS

PR00670
PR00669

PIRSF

SMART

SM00204

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt