InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: INHBA

Summary

InnateDB Gene

IDBG-13490.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

INHBA

Gene Name

inhibin, beta A

Synonyms

EDF; FRP

Species

Homo sapiens

Ensembl Gene

ENSG00000122641

Encoded Proteins

IDBP-13492

inhibin, beta A

IDBP-372911

inhibin, beta A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta A subunit forms a homodimer, activin A, and also joins with a beta B subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. Finally, it has been shown that the beta A subunit mRNA is identical to the erythroid differentiation factor subunit mRNA and that only one gene for this mRNA exists in the human genome. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:41685114-41703108

Strand

Reverse strand

Band

p14.1

Transcripts

ENST00000242208	ENSP00000242208
ENST00000442711	ENSP00000397197
ENST00000464515

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	13 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005125	cytokine activity
GO:0005179	hormone activity
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0017046	peptide hormone binding
GO:0042802	identical protein binding
GO:0046982	protein heterodimerization activity
GO:0070699	type II activin receptor binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0001541	ovarian follicle development
GO:0001707	mesoderm formation
GO:0001942	hair follicle development
GO:0002244	hematopoietic progenitor cell differentiation
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006952	defense response
GO:0007050	cell cycle arrest
GO:0007166	cell surface receptor signaling pathway
GO:0007267	cell-cell signaling
GO:0007399	nervous system development
GO:0008285	negative regulation of cell proliferation
GO:0008584	male gonad development
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0030154	cell differentiation
GO:0030218	erythrocyte differentiation
GO:0030308	negative regulation of cell growth
GO:0032270	positive regulation of cellular protein metabolic process
GO:0032924	activin receptor signaling pathway
GO:0035987	endodermal cell differentiation
GO:0040007	growth
GO:0042326	negative regulation of phosphorylation
GO:0042476	odontogenesis
GO:0042493	response to drug
GO:0042541	hemoglobin biosynthetic process
GO:0042701	progesterone secretion
GO:0045077	negative regulation of interferon-gamma biosynthetic process
GO:0045578	negative regulation of B cell differentiation
GO:0045648	positive regulation of erythrocyte differentiation
GO:0045650	negative regulation of macrophage differentiation
GO:0045786	negative regulation of cell cycle
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046880	regulation of follicle-stimulating hormone secretion
GO:0046881	positive regulation of follicle-stimulating hormone secretion
GO:0046882	negative regulation of follicle-stimulating hormone secretion
GO:0048333	mesodermal cell differentiation
GO:0060021	palate development
GO:0060279	positive regulation of ovulation
GO:0061029	eyelid development in camera-type eye
GO:0071372	cellular response to follicle-stimulating hormone stimulus
GO:0071397	cellular response to cholesterol
GO:0097191	extrinsic apoptotic signaling pathway
GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand