Homo sapiens Gene: INHBA
Summary
InnateDB Gene IDBG-13490.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol INHBA
Gene Name inhibin, beta A
Synonyms EDF; FRP;
Species Homo sapiens
Ensembl Gene ENSG00000122641
Encoded Proteins
inhibin, beta A
inhibin, beta A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta A subunit forms a homodimer, activin A, and also joins with a beta B subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. Finally, it has been shown that the beta A subunit mRNA is identical to the erythroid differentiation factor subunit mRNA and that only one gene for this mRNA exists in the human genome. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:41685114-41703108
Strand Reverse strand
Band p14.1
Transcripts
ENST00000242208 ENSP00000242208
ENST00000442711 ENSP00000397197
ENST00000464515
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 13 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005125 cytokine activity
GO:0005179 hormone activity
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0017046 peptide hormone binding
GO:0042802 identical protein binding
GO:0046982 protein heterodimerization activity
GO:0070699 type II activin receptor binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0001541 ovarian follicle development
GO:0001707 mesoderm formation
GO:0001942 hair follicle development
GO:0002244 hematopoietic progenitor cell differentiation
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006952 defense response
GO:0007050 cell cycle arrest
GO:0007166 cell surface receptor signaling pathway
GO:0007267 cell-cell signaling
GO:0007399 nervous system development
GO:0008285 negative regulation of cell proliferation
GO:0008584 male gonad development
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0030154 cell differentiation
GO:0030218 erythrocyte differentiation
GO:0030308 negative regulation of cell growth
GO:0032270 positive regulation of cellular protein metabolic process
GO:0032924 activin receptor signaling pathway
GO:0035987 endodermal cell differentiation
GO:0040007 growth
GO:0042326 negative regulation of phosphorylation
GO:0042476 odontogenesis
GO:0042493 response to drug
GO:0042541 hemoglobin biosynthetic process
GO:0042701 progesterone secretion
GO:0045077 negative regulation of interferon-gamma biosynthetic process
GO:0045578 negative regulation of B cell differentiation
GO:0045648 positive regulation of erythrocyte differentiation
GO:0045650 negative regulation of macrophage differentiation
GO:0045786 negative regulation of cell cycle
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046880 regulation of follicle-stimulating hormone secretion
GO:0046881 positive regulation of follicle-stimulating hormone secretion
GO:0046882 negative regulation of follicle-stimulating hormone secretion
GO:0048333 mesodermal cell differentiation
GO:0060021 palate development
GO:0060279 positive regulation of ovulation
GO:0061029 eyelid development in camera-type eye
GO:0071372 cellular response to follicle-stimulating hormone stimulus
GO:0071397 cellular response to cholesterol
GO:0097191 extrinsic apoptotic signaling pathway
GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0005576 extracellular region
GO:0043509 activin A complex
GO:0043512 inhibin A complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Glycoprotein hormones pathway
Signal Transduction pathway
Metabolism of proteins pathway
Antagonism of Activin by Follistatin pathway
Peptide hormone biosynthesis pathway
Peptide hormone metabolism pathway
Signaling by Activin pathway
KEGG
Cytokine-cytokine receptor interaction pathway
TGF-beta signaling pathway pathway
INOH
GPCR signaling pathway
TGF-beta signaling pathway
BMP2 signaling pathway
PID BIOCARTA
PID NCI
ALK1 signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.28792 Hs.583348 Hs.604940 Hs.689272 Hs.706943 Hs.737347
RefSeq NM_002192
HUGO
OMIM
CCDS CCDS5464
HPRD 00929
IMGT
EMBL
GenPept
RNA Seq Atlas