InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: E2F5

Summary

InnateDB Protein

IDBP-373009.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

E2F5

Protein Name

E2F transcription factor 5, p130-binding

Synonyms

E2F-5;

Species

Homo sapiens

Ensembl Protein

ENSP00000398124

InnateDB Gene

IDBG-27065 (E2F5)

Protein Structure

UniProt Annotation

Function

Transcriptional activator that binds to E2F sites, these sites are present in the promoter of many genes whose products are involved in cell proliferation. May mediate growth factor- initiated signal transduction. It is likely involved in the early responses of resting cells to growth factor stimulation.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	11 [view]
Protein-DNA	10 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0009887	organ morphogenesis
GO:0010467	gene expression
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051726	regulation of cell cycle