Homo sapiens Gene: E2F5
Summary
InnateDB Gene IDBG-27065.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol E2F5
Gene Name E2F transcription factor 5, p130-binding
Synonyms E2F-5;
Species Homo sapiens
Ensembl Gene ENSG00000133740
Encoded Proteins
E2F transcription factor 5, p130-binding
E2F transcription factor 5, p130-binding
E2F transcription factor 5, p130-binding
E2F transcription factor 5, p130-binding
E2F transcription factor 5, p130-binding
E2F transcription factor 5, p130-binding
E2F transcription factor 5, p130-binding
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionarily conserved domains that are present in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein is differentially phosphorylated and is expressed in a wide variety of human tissues. It has higher identity to E2F4 than to other family members. Both this protein and E2F4 interact with tumor suppressor proteins p130 and p107, but not with pRB. Alternative splicing results in multiple variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:85177225-85217158
Strand Forward strand
Band q21.2
Transcripts
ENST00000256117 ENSP00000256117
ENST00000418930 ENSP00000414312
ENST00000416274 ENSP00000398124
ENST00000517476 ENSP00000429120
ENST00000521429 ENSP00000428606
ENST00000521234
ENST00000518234 ENSP00000429669
ENST00000520225 ENSP00000430461
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 21 [view]
Protein-Protein 11 [view]
Protein-DNA 10 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0009887 organ morphogenesis
GO:0010467 gene expression
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
TGF_beta_Receptor pathway
REACTOME
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription pathway
G1 Phase pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
Loss of Function of SMAD4 in Cancer pathway
Loss of Function of SMAD2/3 in Cancer pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
Mitotic G1-G1/S phases pathway
Cyclin D associated events in G1 pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
Signal Transduction pathway
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
Loss of Function of TGFBR2 in Cancer pathway
Cell Cycle pathway
Generic Transcription Pathway pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
G0 and Early G1 pathway
TGFBR1 KD Mutants in Cancer pathway
Cell Cycle, Mitotic pathway
Loss of Function of TGFBR1 in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
Gene Expression pathway
Disease pathway
Signaling by TGF-beta Receptor Complex pathway
KEGG
Cell cycle pathway
TGF-beta signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
E2F transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.445758
RefSeq NM_001083588 NM_001083589 NM_001951 XM_006716434
HUGO
OMIM
CCDS CCDS47885 CCDS47886 CCDS55254
HPRD 02983
IMGT
EMBL
GenPept
RNA Seq Atlas