Version 5.4
Homo sapiens Protein: HIGD1A
Summary
InnateDB Protein IDBP-373657.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HIGD1A
Protein Name HIG1 hypoxia inducible domain family, member 1A
Synonyms HIG1; RCF1a;
Species Homo sapiens
Ensembl Protein ENSP00000402160
InnateDB Gene IDBG-28084 (HIGD1A)
Protein Structure
UniProt Annotation
Function Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May play a role in the assembly of respiratory supercomplexes. {ECO:0000269PubMed:22342701}.
Subcellular Localization Mitochondrion membrane {ECO:0000255PROSITE- ProRule:PRU00836, ECO:0000269PubMed:22342701}; Multi-pass membrane protein {ECO:0000255PROSITE-ProRule:PRU00836, ECO:0000269PubMed:22342701}. Mitochondrion inner membrane {ECO:0000305PubMed:22342701}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006950 response to stress
GO:0043066 negative regulation of apoptotic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005743 mitochondrial inner membrane
GO:0016021 integral component of membrane
GO:0043234 protein complex
GO:0070469 respiratory chain
Protein Structure and Domains
PDB ID
InterPro IPR007667 Hypoxia induced protein, domain
PFAM PF04588
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y241
PhosphoSite PhosphoSite-Q9Y241
TrEMBL A0A024R2M9
UniProt Splice Variant
Entrez Gene 25994
UniGene
RefSeq
HUGO HGNC:29527
OMIM
CCDS CCDS43073
HPRD 13651
IMGT
EMBL AF077034 AF145385 AL110233 BC000601 BC009583 BC009594 BC070277 BG400624 CH471055 CR457385
GenPept AAD27767 AAD33954 AAH00601 AAH09583 AAH09594 AAH70277 CAB53686 CAG33666 EAW64673 EAW64677

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca