InnateDB Protein
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IDBP-373658.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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HIGD1A
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Protein Name
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HIG1 hypoxia inducible domain family, member 1A
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Synonyms
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HIG1; RCF1a;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000398064
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InnateDB Gene
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IDBG-28084 (HIGD1A)
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Protein Structure
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Function |
Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May play a role in the assembly of respiratory supercomplexes. {ECO:0000269PubMed:22342701}.
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Subcellular Localization |
Mitochondrion membrane {ECO:0000255PROSITE- ProRule:PRU00836, ECO:0000269PubMed:22342701}; Multi-pass membrane protein {ECO:0000255PROSITE-ProRule:PRU00836, ECO:0000269PubMed:22342701}. Mitochondrion inner membrane {ECO:0000305PubMed:22342701}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
4
[view]
|
Protein-Protein |
4
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR007667
Hypoxia induced protein, domain
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PFAM |
PF04588
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Y241
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PhosphoSite |
PhosphoSite-Q9Y241
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TrEMBL |
A0A024R2M9
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UniProt Splice Variant |
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Entrez Gene |
25994
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UniGene |
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RefSeq |
NP_001093138
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HUGO |
HGNC:29527
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OMIM |
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CCDS |
CCDS46806
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HPRD |
13651
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IMGT |
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EMBL |
AF077034
AF145385
AL110233
BC000601
BC009583
BC009594
BC070277
BG400624
CH471055
CR457385
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GenPept |
AAD27767
AAD33954
AAH00601
AAH09583
AAH09594
AAH70277
CAB53686
CAG33666
EAW64673
EAW64677
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