InnateDB Protein
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IDBP-374062.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ERAP1
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Protein Name
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endoplasmic reticulum aminopeptidase 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000406304
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InnateDB Gene
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IDBG-34697 (ERAP1)
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Protein Structure
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Function |
Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I- binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney. {ECO:0000269PubMed:15908954, ECO:0000269PubMed:16286653, ECO:0000269PubMed:21478864}.
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Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000305PubMed:15908954}; Single-pass type II membrane protein {ECO:0000305PubMed:15908954}.
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Disease Associations |
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Tissue Specificity |
Ubiquitous.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
10
[view]
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Protein-Protein |
9
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR014782
Peptidase M1, membrane alanine aminopeptidase, N-terminal
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PFAM |
PF01433
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PRINTS |
PR00756
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9NZ08
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PhosphoSite |
PhosphoSite-Q9NZ08
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TrEMBL |
D6RAL9
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UniProt Splice Variant |
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Entrez Gene |
51752
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UniGene |
Hs.666524
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RefSeq |
NP_001185470
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HUGO |
HGNC:18173
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OMIM |
606832
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CCDS |
CCDS47250
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HPRD |
06015
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IMGT |
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EMBL |
AB011097
AC008906
AF106037
AF183569
AF222340
AY028806
AY028807
AY358590
BC030775
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GenPept |
AAF07395
AAF20384
AAF34664
AAH30775
AAK37777
AAK37778
AAQ88953
BAA25451
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