InnateDB Protein
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IDBP-37464.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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DIS3
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Protein Name
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DIS3 mitotic control homolog (S. cerevisiae)
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Synonyms
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2810028N01Rik; dis3p; EXOSC11; KIAA1008; RRP44;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000367011
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InnateDB Gene
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IDBG-37462 (DIS3)
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Protein Structure
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Function |
Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3'-5' exonuclease and endonuclease activities. {ECO:0000269PubMed:19056938, ECO:0000269PubMed:20531386}.
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Subcellular Localization |
Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus. Note=Predominantly located in the nucleus. According to PubMed:12429849, found in the nucleolus and according to PubMed:20531386, excluded from nucleolus supporting the existence of a nucleolar RNA exosome complex devoid of DIS3.
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Disease Associations |
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Tissue Specificity |
Widely expressed.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
33
[view]
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Protein-Protein |
32
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0000288
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nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
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GO:0006364
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rRNA processing
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GO:0010467
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gene expression
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GO:0016070
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RNA metabolic process
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GO:0016071
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mRNA metabolic process
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GO:0016075
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rRNA catabolic process
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GO:0043547
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positive regulation of GTPase activity
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GO:0043928
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exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
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GO:0071034
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CUT catabolic process
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GO:0090305
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nucleic acid phosphodiester bond hydrolysis
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GO:0090503
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RNA phosphodiester bond hydrolysis, exonucleolytic
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Cellular Component |
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PDB ID |
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InterPro |
IPR029060
PIN domain-like
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Y2L1
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PhosphoSite |
PhosphoSite-Q9Y2L1
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TrEMBL |
G3V1J5
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UniProt Splice Variant |
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Entrez Gene |
22894
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UniGene |
Hs.643464
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RefSeq |
NP_001121698
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HUGO |
HGNC:20604
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OMIM |
607533
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CCDS |
CCDS45057
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HPRD |
06338
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IMGT |
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EMBL |
AB023225
AF330044
AK001346
AK314715
AL080158
AL138695
AL391384
AL832266
BC056143
CH471093
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GenPept |
AAH56143
AAL37479
BAA76852
BAG37259
BAG50895
CAB45749
CAH56266
CAH72708
CAH72709
CAI15670
CAI15671
EAW80517
EAW80519
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