Homo sapiens Gene: DIS3
Summary
InnateDB Gene IDBG-37462.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DIS3
Gene Name DIS3 mitotic control homolog (S. cerevisiae)
Synonyms 2810028N01Rik; dis3p; EXOSC11; KIAA1008; RRP44;
Species Homo sapiens
Ensembl Gene ENSG00000083520
Encoded Proteins
DIS3 mitotic control homolog (S. cerevisiae)
DIS3 mitotic control homolog (S. cerevisiae)
DIS3 mitotic control homolog (S. cerevisiae)
DIS3 mitotic control homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 13:72752169-72782096
Strand Reverse strand
Band q21.33
Transcripts
ENST00000377780 ENSP00000367011
ENST00000377767 ENSP00000366997
ENST00000490646 ENSP00000436350
ENST00000475871
ENST00000545453 ENSP00000440058
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
Experimentally validated
Total 33 [view]
Protein-Protein 32 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000175 3'-5'-exoribonuclease activity
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
Biological Process
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0006364 rRNA processing
GO:0010467 gene expression
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0016075 rRNA catabolic process
GO:0043547 positive regulation of GTPase activity
GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
GO:0071034 CUT catabolic process
GO:0090305 nucleic acid phosphodiester bond hydrolysis
GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic
Cellular Component
GO:0000176 nuclear exosome (RNase complex)
GO:0000178 exosome (RNase complex)
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Unfolded Protein Response (UPR) pathway
ATF4 activates genes pathway
Tristetraprolin (TTP) destabilizes mRNA pathway
Deadenylation-dependent mRNA decay pathway
Butyrate Response Factor 1 (BRF1) destabilizes mRNA pathway
mRNA decay by 3' to 5' exoribonuclease pathway
Metabolism of proteins pathway
PERK regulates gene expression pathway
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
Gene Expression pathway
KSRP destabilizes mRNA pathway
KEGG
RNA degradation pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9Y2L1
TrEMBL B3KM83 G3V1J5
UniProt Splice Variant
Entrez Gene 22894
UniGene Hs.643464
RefSeq NM_001128226 NM_014953
HUGO HGNC:20604
OMIM 607533
CCDS CCDS45057 CCDS9447
HPRD 06338
IMGT
EMBL AB023225 AF330044 AK001346 AK314715 AL080158 AL138695 AL391384 AL832266 BC056143 CH471093
GenPept AAH56143 AAL37479 BAA76852 BAG37259 BAG50895 CAB45749 CAH56266 CAH72708 CAH72709 CAI15670 CAI15671 EAW80517 EAW80519
RNA Seq Atlas 22894