Homo sapiens Protein: EIF4E
InnateDB Protein IDBP-374716.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF4E
Protein Name eukaryotic translation initiation factor 4E
Synonyms AUTS19; CBP; EIF4E1; EIF4EL1; EIF4F;
Species Homo sapiens
Ensembl Protein ENSP00000389624
InnateDB Gene IDBG-30970 (EIF4E)
Protein Structure
UniProt Annotation
Function Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap. {ECO:0000269PubMed:16271312, ECO:0000269PubMed:22578813}.
Subcellular Localization Cytoplasm, P-body {ECO:0000269PubMed:20616046}. Cytoplasm {ECO:0000250}.
Disease Associations Autism 19 (AUTS19) [MIM:615091]: A complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate mental retardation. {ECO:0000269PubMed:19556253}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. A heterozygous single-nucleotide insertion has been found in families affected by autism. The variant results in increased promoter activity and is involved in disease pathogenesis through EIF4E deregulation (PubMed:19556253). {ECO:0000269PubMed:19556253}.Note=A chromosomal aberration involving EIF4E has been found in a patient with classic autism. Translocation t(45)(q23q31.3). The breakpoint on chromosome 4 is located 56 kb downstream of EIF4E (PubMed:19556253). {ECO:0000269PubMed:19556253}.
Tissue Specificity
Number of Interactions This gene and/or its encoded proteins are associated with 96 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 96 [view]
Protein-Protein 91 [view]
Protein-DNA 2 [view]
Protein-RNA 2 [view]
DNA-DNA 1 [view]
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000339 RNA cap binding
GO:0003723 RNA binding
GO:0003743 translation initiation factor activity
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening
GO:0006406 mRNA export from nucleus
GO:0006412 translation
GO:0006413 translational initiation
GO:0006417 regulation of translation
GO:0008286 insulin receptor signaling pathway
GO:0010467 gene expression
GO:0016032 viral process
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0019221 cytokine-mediated signaling pathway
GO:0044267 cellular protein metabolic process
GO:0045087 innate immune response (InnateDB)
GO:0045931 positive regulation of mitotic cell cycle
Cellular Component
GO:0000932 cytoplasmic mRNA processing body
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005845 mRNA cap binding complex
GO:0010494 cytoplasmic stress granule
GO:0016281 eukaryotic translation initiation factor 4F complex
GO:0016442 RISC complex
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
InterPro IPR001040 Translation Initiation factor eIF- 4e
IPR023398 Translation Initiation factor eIF- 4e-like domain
PFAM PF01652
Post-translational Modifications
SwissProt P06730
PhosphoSite PhosphoSite-P06730
UniProt Splice Variant
Entrez Gene 1977
UniGene Hs.596163
RefSeq NP_001959
OMIM 133440
HPRD 00591
EMBL AC019131 AC093836 AK300982 BC012611 BC035166 BC043226 BM849222 M15353
GenPept AAC13647 AAH12611 AAH35166 AAH43226 BAH13387