Version 5.4
Homo sapiens Gene: EIF4E
Summary
InnateDB Gene IDBG-30970.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF4E
Gene Name eukaryotic translation initiation factor 4E
Synonyms AUTS19; CBP; EIF4E1; EIF4EL1; EIF4F
Species Homo sapiens
Ensembl Gene ENSG00000151247
Encoded Proteins
IDBP-30972
eukaryotic translation initiation factor 4E
IDBP-374716
eukaryotic translation initiation factor 4E
IDBP-476057
eukaryotic translation initiation factor 4E
IDBP-484928
eukaryotic translation initiation factor 4E
IDBP-480167
eukaryotic translation initiation factor 4E
IDBP-477492
eukaryotic translation initiation factor 4E
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22544393
The regulated phosphorylation of EIF4E has a key role in antiviral host defense by selectively controlling the translation of NFKBIA mRNA, which encodes a critical suppressor of the innate antiviral response. As a result, EIF4E null mice exhibit lower susceptibility to viral infections. (Demonstrated in mice)
InnateDB Annotation from Orthologs
Summary
PMID 22544393
[Mus musculus] The regulated phosphorylation of Eif4e has a key role in antiviral host defense by selectively controlling the translation of Nfkbia mRNA, which encodes a critical suppressor of the innate antiviral response. As a result, Eif4e null mice exhibit lower susceptibility to viral infections.
Entrez Gene
Summary The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of cellular mRNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the mRNA. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5\' end of cellular mRNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the mRNA. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:98871684-98930637
Strand Reverse strand
Band q23
Transcripts
ENST00000280892 ENSP00000280892
ENST00000418385
ENST00000450253 ENSP00000389624
ENST00000515638 ENSP00000426602
ENST00000504432 ENSP00000423977
ENST00000511644 ENSP00000421287
ENST00000505992 ENSP00000425561
ENST00000505194
ENST00000507665
ENST00000505829
ENST00000504472
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 96 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 96 [view]
Protein-Protein 91 [view]
Protein-DNA 2 [view]
Protein-RNA 2 [view]
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000339 RNA cap binding
GO:0003723 RNA binding
GO:0003743 translation initiation factor activity
GO:0005515 protein binding
GO:0031370 eukaryotic initiation factor 4G binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening
GO:0006406 mRNA export from nucleus
GO:0006412 translation
GO:0006413 translational initiation
GO:0006417 regulation of translation
GO:0008286 insulin receptor signaling pathway
GO:0010467 gene expression
GO:0016032 viral process
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0019221 cytokine-mediated signaling pathway
GO:0030324 lung development
GO:0044267 cellular protein metabolic process
GO:0045087 innate immune response (InnateDB)
GO:0045931 positive regulation of mitotic cell cycle
Cellular Component
GO:0000932 cytoplasmic mRNA processing body
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005845 mRNA cap binding complex
GO:0010494 cytoplasmic stress granule
GO:0016281 eukaryotic translation initiation factor 4F complex
GO:0016442 RISC complex
GO:0033391 chromatoid body
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028156
View Gene Order
ENSBTAG00000009522
Not yet available
Pathways
NETPATH
NetPath_1
Alpha6Beta4Integrin pathway
NetPath_14
IL2 pathway
NetPath_18
IL6 pathway
NetPath_22
Leptin pathway
NetPath_24
TSLP pathway
REACTOME
REACT_115831
ISG15 antiviral mechanism pathway
REACT_79
L13a-mediated translational silencing of Ceruloplasmin expression pathway
REACT_6836
Release of eIF4E pathway
REACT_6838
mTOR signalling pathway
REACT_976
PI3K Cascade pathway
REACT_498
Signaling by Insulin receptor pathway
REACT_150203
IRS-related events triggered by IGF1R pathway
REACT_150359
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_20514
Deadenylation of mRNA pathway
REACT_2085
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
REACT_1979
Translation initiation complex formation pathway
REACT_1258
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
REACT_931
Ribosomal scanning and start codon recognition pathway
REACT_1597
Transport of Mature mRNA derived from an Intron-Containing Transcript pathway
REACT_424
Transport of the SLBP independent Mature mRNA pathway
REACT_405
Transport of the SLBP Dependant Mature mRNA pathway
REACT_1835
Transport of Mature mRNA Derived from an Intronless Transcript pathway
REACT_125
Processing of Capped Intron-Containing Pre-mRNA pathway
REACT_2159
Eukaryotic Translation Initiation pathway
REACT_456
PKB-mediated events pathway
REACT_20639
Deadenylation-dependent mRNA decay pathway
REACT_115676
Antiviral mechanism by IFN-stimulated genes pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_6964
mTORC1-mediated signalling pathway
REACT_1014
Translation pathway
REACT_111102
Signal Transduction pathway
REACT_25229
Interferon Signaling pathway
REACT_332
IRS-mediated signalling pathway
REACT_17015
Metabolism of proteins pathway
REACT_6900
Immune System pathway
REACT_1195
Insulin receptor signalling cascade pathway
REACT_1281
Transport of Mature Transcript to Cytoplasm pathway
REACT_2099
Cap-dependent Translation Initiation pathway
REACT_762
IRS-related events pathway
REACT_150210
IGF1R signaling cascade pathway
REACT_338
Transport of Mature mRNAs Derived from Intronless Transcripts pathway
REACT_71
Gene Expression pathway
KEGG
hsa04150
mTOR signaling pathway pathway
hsa04910
Insulin signaling pathway pathway
hsa03013
RNA transport pathway
INOH
INOH website
Insulin receptor signaling pathway
PID NCI
met_pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
mtor_4pathway
mTOR signaling pathway
myc_activpathway
Validated targets of C-MYC transcriptional activation
p38alphabetadownstreampathway
Signaling mediated by p38-alpha and p38-beta
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.13211 Hs.596163
RefSeq NM_001130678 NM_001130679 NM_001968 XM_006714127
HUGO
OMIM
CCDS CCDS34031 CCDS47109 CCDS54779
HPRD 00591
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca