InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ASIC1

Summary

InnateDB Protein

IDBP-374749.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ASIC1

Protein Name

amiloride-sensitive cation channel 2, neuronal

Synonyms

ACCN2; ASIC; BNaC2;

Species

Homo sapiens

Ensembl Protein

ENSP00000400228

InnateDB Gene

IDBG-32261 (ASIC1)

Protein Structure

UniProt Annotation

Function

Isoform 2 and isoform 3 function as proton-gated sodium channels; they are activated by a drop of the extracellular pH and then become rapidly desensitized. The channel generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Isoform 2 can also transport potassium, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Isoform 3 can also transport calcium ions. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear. {ECO:0000269PubMed:22760635}.Isoform 1 does not display proton-gated cation channel activity. {ECO:0000269PubMed:22760635}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:12578970, ECO:0000269PubMed:21036899, ECO:0000269PubMed:22760635}; Multi- pass membrane protein {ECO:0000269PubMed:12578970, ECO:0000269PubMed:21036899, ECO:0000269PubMed:22760635}. Note=Localizes in synaptosomes at dendritic synapses of neurons. Colocalizes with DLG4 (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in most or all neurons.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005272	sodium channel activity
GO:0005515	protein binding
GO:0015280	ligand-gated sodium channel activity
GO:0044736	acid-sensing ion channel activity

Biological Process

GO:0006810	transport
GO:0006814	sodium ion transport
GO:0007165	signal transduction
GO:0009268	response to pH
GO:0034220	ion transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0050915	sensory perception of sour taste
GO:0055085	transmembrane transport
GO:0070207	protein homotrimerization
GO:0071467	cellular response to pH