InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HLA-DMB

Summary

InnateDB Protein

IDBP-374757.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HLA-DMB

Protein Name

major histocompatibility complex, class II, DM beta

Synonyms

D6S221E; RING7;

Species

Homo sapiens

Ensembl Protein

ENSP00000398890

InnateDB Gene

IDBG-403749 (HLA-DMB)

Protein Structure

UniProt Annotation

Function

Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. {ECO:0000269PubMed:16547258, ECO:0000269PubMed:8849454, ECO:0000269PubMed:9768757}.

Subcellular Localization

Late endosome membrane {ECO:0000269PubMed:8757605}; Single-pass type I membrane protein {ECO:0000269PubMed:8757605}. Lysosome membrane {ECO:0000269PubMed:8757605}; Single-pass type I membrane protein {ECO:0000269PubMed:8757605}. Note=Localizes to late endocytic compartment. Associates with lysosome membranes.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0023026	MHC class II protein complex binding

Biological Process

GO:0002399	MHC class II protein complex assembly
GO:0002503	peptide antigen assembly with MHC class II protein complex
GO:0006955	immune response
GO:0019882	antigen processing and presentation
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0042102	positive regulation of T cell proliferation
GO:2001190	positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

Cellular Component

GO:0005765	lysosomal membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031902	late endosome membrane
GO:0042613	MHC class II protein complex

Protein Structure and Domains

PDB ID

InterPro

IPR000353 MHC class II, beta chain, N-terminal
IPR003597 Immunoglobulin C1-set
IPR007110 Immunoglobulin-like domain
IPR011162 MHC classes I/II-like antigen recognition protein
IPR013162 CD80-like, immunoglobulin C2-set

PFAM

PF00969
PF07654
PF08205

PRINTS

PIRSF

SMART

SM00921
SM00407

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P28068