Version 5.4
Homo sapiens Gene: HLA-DMB
Summary
InnateDB Gene IDBG-403749.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HLA-DMB
Gene Name major histocompatibility complex, class II, DM beta
Synonyms D6S221E; RING7
Species Homo sapiens
Ensembl Gene ENSG00000242574
Encoded Proteins
IDBP-374746
major histocompatibility complex, class II, DM beta
IDBP-374750
major histocompatibility complex, class II, DM beta
IDBP-374757
major histocompatibility complex, class II, DM beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:32934629-32941070
Strand Reverse strand
Band p21.32
Transcripts
ENST00000414017 ENSP00000411276
ENST00000438510 ENSP00000390848
ENST00000418107 ENSP00000398890
ENST00000477537
ENST00000498020
ENST00000487996
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0023026 MHC class II protein complex binding
Biological Process
GO:0002399 MHC class II protein complex assembly
GO:0002503 peptide antigen assembly with MHC class II protein complex
GO:0006955 immune response
GO:0019882 antigen processing and presentation
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0042102 positive regulation of T cell proliferation
GO:2001190 positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
Cellular Component
GO:0005765 lysosomal membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031902 late endosome membrane
GO:0042613 MHC class II protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000037548
View Gene Order
ENSBTAG00000012451
Not yet available
Pathways
NETPATH
REACTOME
REACT_121399
MHC class II antigen presentation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
hsa04612
Antigen processing and presentation pathway
hsa04940
Type I diabetes mellitus pathway
hsa05330
Allograft rejection pathway
hsa05320
Autoimmune thyroid disease pathway
hsa05322
Systemic lupus erythematosus pathway
hsa05332
Graft-versus-host disease pathway
hsa05310
Asthma pathway
hsa04672
Intestinal immune network for IgA production pathway
hsa05416
Viral myocarditis pathway
hsa05140
Leishmaniasis pathway
hsa05150
Staphylococcus aureus infection pathway
hsa05145
Toxoplasmosis pathway
hsa04145
Phagosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.351279 Hs.601376 Hs.614506
RefSeq NM_002118
HUGO
OMIM
CCDS CCDS4760
HPRD 00831
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca