InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AP1M1

Summary

InnateDB Protein

IDBP-374847.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AP1M1

Protein Name

adaptor-related protein complex 1, mu 1 subunit

Synonyms

AP47; CLAPM2; CLTNM; MU-1A;

Species

Homo sapiens

Ensembl Protein

ENSP00000388996

InnateDB Gene

IDBG-35433 (AP1M1)

Protein Structure

UniProt Annotation

Function

Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.

Subcellular Localization

Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	31 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006810	transport
GO:0006886	intracellular protein transport
GO:0006892	post-Golgi vesicle-mediated transport
GO:0015031	protein transport
GO:0016032	viral process
GO:0016192	vesicle-mediated transport
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0032438	melanosome organization
GO:0035646	endosome to melanosome transport
GO:0050690	regulation of defense response to virus by virus
GO:0061024	membrane organization

Cellular Component

GO:0000139	Golgi membrane
GO:0005765	lysosomal membrane
GO:0005829	cytosol
GO:0016020	membrane
GO:0030131	clathrin adaptor complex
GO:0030659	cytoplasmic vesicle membrane
GO:0030665	clathrin-coated vesicle membrane
GO:0032588	trans-Golgi network membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001392 Clathrin adaptor, mu subunit
IPR008968 Clathrin adaptor, mu subunit, C-terminal
IPR011012 Longin-like domain
IPR022775 AP complex, mu/sigma subunit
IPR028565 Mu homology domain

PFAM

PF00928
PF01217

PRINTS

PR00314

PIRSF

PIRSF005992

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt