Version 5.4
Homo sapiens Gene: AP1M1
Summary
InnateDB Gene IDBG-35433.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AP1M1
Gene Name adaptor-related protein complex 1, mu 1 subunit
Synonyms AP47; CLAPM2; CLTNM; MU-1A
Species Homo sapiens
Ensembl Gene ENSG00000072958
Encoded Proteins
IDBP-35435
adaptor-related protein complex 1, mu 1 subunit
IDBP-374847
adaptor-related protein complex 1, mu 1 subunit
IDBP-374850
adaptor-related protein complex 1, mu 1 subunit
IDBP-762301
IDBP-762612
IDBP-765340
IDBP-766105
IDBP-764976
IDBP-764042
IDBP-808858
adaptor-related protein complex 1, mu 1 subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is the medium chain of the trans-Golgi network clathrin-associated protein complex AP-1. The other components of this complex are beta-prime-adaptin, gamma-adaptin, and the small chain AP1S1. This complex is located at the Golgi vesicle and links clathrin to receptors in coated vesicles. These vesicles are involved in endocytosis and Golgi processing. Alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:16197578-16245907
Strand Forward strand
Band p13.11
Transcripts
ENST00000291439 ENSP00000291439
ENST00000444449 ENSP00000388996
ENST00000429941 ENSP00000411498
ENST00000586957
ENST00000590756 ENSP00000465224
ENST00000592703
ENST00000590263 ENSP00000466858
ENST00000591966
ENST00000590945 ENSP00000467721
ENST00000589822 ENSP00000468140
ENST00000586543 ENSP00000468015
ENST00000591775 ENSP00000467417
ENST00000589782 ENSP00000482949
ENST00000586461
ENST00000589991
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 32 [view]
Protein-Protein 31 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006810 transport
GO:0006886 intracellular protein transport
GO:0006892 post-Golgi vesicle-mediated transport
GO:0015031 protein transport
GO:0016032 viral process
GO:0016192 vesicle-mediated transport
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0032438 melanosome organization
GO:0035646 endosome to melanosome transport
GO:0050690 regulation of defense response to virus by virus
GO:0061024 membrane organization
Cellular Component
GO:0000139 Golgi membrane
GO:0005765 lysosomal membrane
GO:0005829 cytosol
GO:0016020 membrane
GO:0030131 clathrin adaptor complex
GO:0030659 cytoplasmic vesicle membrane
GO:0030665 clathrin-coated vesicle membrane
GO:0032588 trans-Golgi network membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000003033
View Gene Order
ENSBTAG00000013329
Not yet available
Pathways
NETPATH
REACTOME
REACT_121399
MHC class II antigen presentation pathway
REACT_11103
Nef mediated downregulation of MHC class I complex cell surface expression pathway
REACT_19287
Lysosome Vesicle Biogenesis pathway
REACT_19400
Golgi Associated Vesicle Biogenesis pathway
REACT_19187
Clathrin derived vesicle budding pathway
REACT_11235
trans-Golgi Network Vesicle Budding pathway
REACT_11149
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_6185
HIV Infection pathway
REACT_6835
The role of Nef in HIV-1 replication and disease pathogenesis pathway
REACT_6288
Host Interactions of HIV factors pathway
REACT_116125
Disease pathway
REACT_11123
Membrane Trafficking pathway
KEGG
hsa04142
Lysosome pathway
INOH
PID NCI
ecadherin_nascentaj_pathway
E-cadherin signaling in the nascent adherens junction
Cross-References
SwissProt
TrEMBL K7EPJ8 K7EQ90 K7ER75
UniProt Splice Variant
Entrez Gene 8907
UniGene Hs.619927 Hs.71040
RefSeq NM_001130524 NM_032493
HUGO HGNC:13667
OMIM 603535
CCDS CCDS12342 CCDS46008
HPRD 04639
IMGT
EMBL AC020911
GenPept
RNA Seq Atlas 8907

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca