Version 5.4
Homo sapiens Protein: MPST
Summary
InnateDB Protein IDBP-375053.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MPST
Protein Name mercaptopyruvate sulfurtransferase
Synonyms MST; TST2;
Species Homo sapiens
Ensembl Protein ENSP00000411719
InnateDB Gene IDBG-6249 (MPST)
Protein Structure
UniProt Annotation
Function Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. Detoxifies cyanide and is required for thiosulfate biosynthesis. Acts as an antioxidant. In combination with cysteine aminotransferase (CAT), contributes to the catabolism of cysteine and is an important producer of hydrogen sulfide in the brain, retina and vascular endothelial cells. Hydrogen sulfide H(2)S is an important synaptic modulator, signaling molecule, smooth muscle contractor and neuroprotectant. Its production by the 3MST/CAT pathway is regulated by calcium ions (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Mitochondrion {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}.
Disease Associations Note=Aberrant MPST activity is found in a few cases of mercaptolactate-cysteine disulfiduria (MCDU) characterized by the appearance of large quantaties of the sulfur-containing amino acid, beta-mercaptolactate-cysteine disulfide, in the urine (PubMed:4973015, PubMed:4690911 and PubMed:6945862). Some cases have associated mental retardation (PubMed:4973015 and PubMed:6945862).
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004792 thiosulfate sulfurtransferase activity
GO:0016784 3-mercaptopyruvate sulfurtransferase activity
Biological Process
GO:0009440 cyanate catabolic process
GO:0009636 response to toxic substance
GO:0070814 hydrogen sulfide biosynthetic process
Cellular Component
GO:0005739 mitochondrion
GO:0030054 cell junction
GO:0043005 neuron projection
GO:0045202 synapse
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001763 Rhodanese-like domain
PFAM PF00581
PRINTS
PIRSF
SMART SM00450
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P25325
PhosphoSite PhosphoSite-P25325
TrEMBL Q2VEU1
UniProt Splice Variant
Entrez Gene 4357
UniGene Hs.248267
RefSeq NP_066949
HUGO HGNC:7223
OMIM 602496
CCDS CCDS13939
HPRD 11896
IMGT
EMBL AK055733 BC003508 BC016737 BC018717 BT019636 CH471095 CR456523 CR541712 DQ211531 DQ211532 DQ211533 X59434 Z73420
GenPept AAH03508 AAH16737 AAH18717 AAV38442 ABB16334 ABB16335 ABB16336 BAG51564 CAA42060 CAG30409 CAG46513 EAW60133 EAW60134 EAW60135

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca